Evidence map›Paper›PMID 34834328›Full record

ReviewPharmaceutics2021

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases.

Yuan-Pin Hung, Yu-Fon Chen, Pei-Jane Tsai, I-Hsiu Huang, Wen-Chien Ko, Jeng-Shiung Jan

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  5. RSC advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Yuan-Pin HungDepartment of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70007, Taiwan.ORCID 0000-0003-1006-705X
Yu-Fon ChenMaster of Biomedicine Program, National Taitung University, Taitung 95092, Taiwan.
Pei-Jane TsaiDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-3370-9839
I-Hsiu HuangDepartment of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA.
Wen-Chien KoDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.ORCID 0000-0001-7497-149X
Jeng-Shiung JanDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-8379-404X
National Cheng Kung University Hospital · TWChest Hospital, Ministry of Health and Welfare · TWNational Cheng Kung University · TWNational Taitung University · TWOklahoma State University Center for Health Sciences · US

Funding

Ministry of Science and Technology, Taiwan 107-2923-M-006-002-MY3Ministry of Science and Technology, Taiwan 108-2221-E-006-034-MY3Ministry of Science and Technology, Taiwan 108-2320-B-006-043-MY3Ministry of Science and Technology, Taiwan 108-2321-B-006-004Ministry of Science and Technology, Taiwan 109-2314-B-006-089-MY3Ministry of Science and Technology, Taiwan 110-2221-E-006 -002 -MY3Ministry of Science and Technology, Taiwan 110-2314-B-675-001
6 · The paper itself

Abstract

Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.

Indexed as

bacterial infectionbiofilmsimplantsnanoparticlepolymerssilver nanoparticle

Identifiers

PMID34834328
PMCPMC8618949
OpenAlexW3214196785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.