Evidence map›Paper›PMID 34834315›Full record

ArticlePharmaceutics2021

Electrospun Nanofiber and Cryogel of Polyvinyl Alcohol Transdermal Patch Containing Diclofenac Sodium: Preparation, Characterization and In Vitro Release Studies.

Shafizah Sa'adon, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Abdul Halim Mohd Yusof, Ahmad Athif Mohd Faudzi, Suresh Sagadevan, Nadirul Hasraf Mat Nayan, Joseph Sahaya Anand, Khairul Anuar Mat Amin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Shafizah Sa'adonBioInspired Device and Tissue Engineering Research Group, Faculty of Engineering, School of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.
Mohamed Nainar Mohamed AnsariInstitute of Power Engineering, Universiti Tenaga Nasional, Kajang 43000, Selangor, Malaysia.
Saiful Izwan Abd RazakBioInspired Device and Tissue Engineering Research Group, Faculty of Engineering, School of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.ORCID 0000-0001-7477-0284
Abdul Halim Mohd YusofFaculty of Engineering, School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.
Ahmad Athif Mohd FaudziCentre for Artificial Intelligence and Robotics, Universiti Teknologi Malaysia, Kuala Lumpur 54100, Malaysia.ORCID 0000-0002-8591-4551
Suresh SagadevanNanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia.
Nadirul Hasraf Mat NayanFaculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, Batu Pahat 86400, Johor, Malaysia.
Joseph Sahaya AnandSustainable and Responsive Manufacturing Group, Faculty of Mechanical and Manufacturing Engineering Technology, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, Malacca 76100, Malacca, Malaysia.ORCID 0000-0003-1918-5589
Khairul Anuar Mat AminFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.ORCID 0000-0003-0551-015X
University of Technology Malaysia · MYTechnical University of Malaysia Malacca · MYTun Hussein Onn University of Malaysia · MYUniversiti Malaysia Terengganu · MYUniversiti Tenaga Nasional · MYUniversity of Malaya · MY

Funding

Innovative Research and Management Centre (iRMC), Universiti Tenaga Nasional, Malaysia BOLD grant (J510050002)Universiti Teknologi Malaysia 04G53
6 · The paper itself

Abstract

Transdermal drug delivery systems (TDDS) have drawn more interest from pharmaceutical scientists because they could provide steady blood levels and prevent the first-pass metabolism over a longer period. Polyvinyl alcohol (PVA) has been widely used in this application due to its biocompatibility, non-toxicity, nanofiber and hydrogel-forming ability. Despite those benefits, their morphology would easily be destroyed by continuous water absorption and contribute to burst drug release due to its hydrophilicity. The aim of this study was to prepare the diclofenac sodium (DS)-medicated dual layer PVA patch using a combination of electrospinning and cryogelation (freeze-thaw) methods to improve the physicochemical properties and drug compatibility and investigate the release of the DS-medicated dual layer PVA patch. Morphological observations using scanning electron microscopy (SEM) verified the polymer-polymer interaction between both layers, whereas Fourier transform infrared (FTIR) spectroscopy has demonstrated the compatibility of DS in PVA matrix up to 2%

Indexed as

cryogelationdiclofenac sodiumdual layerelectrospinningFranz diffusionin vitro releasenanofiberspolyvinyl alcoholtransdermal drug delivery

Identifiers

PMID34834315
PMCPMC8625409
OpenAlexW3212396669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.