Evidence map›Paper›PMID 34834303›Full record

ArticlePharmaceutics2021

Effective Treatment against ESBL-Producing

Iván A González, Annegrett Palavecino, Constanza Núñez, Paulina Dreyse, Felipe Melo-González, Susan M Bueno, Christian Erick Palavecino

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Photoinactivation of microorganisms using bacteriochlorins as photosensitizers.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Iván A GonzálezDepartamento de Química, Facultad de Ciencias Naturales, Matemática y del Medio Ambiente, Universidad Tecnológica Metropolitana, Las Palmeras 3360, Ñuñoa, Santiago 7800003, Chile.
Annegrett PalavecinoLaboratorio de Microbiología Celular, Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Lord Cochrane 418, Santiago 8330546, Chile.
Constanza NúñezLaboratorio de Microbiología Celular, Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Lord Cochrane 418, Santiago 8330546, Chile.
Paulina DreyseDepartamento de Química, Universidad Técnica Federico Santa María, Av. España 1680, Casilla, Valparaíso 2390123, Chile.
Felipe Melo-GonzálezDepartamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.
Susan M BuenoDepartamento de Genética Molecular y Microbiología, Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID 0000-0002-7551-8088
Christian Erick PalavecinoLaboratorio de Microbiología Celular, Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Lord Cochrane 418, Santiago 8330546, Chile.ORCID 0000-0002-4581-7327
Universidad Central de Chile · CLPontificia Universidad Católica de Chile · CLFederico Santa María Technical University · CLMetropolitan University of Technology · CL

Funding

Agencia Nacional de Investigación y Desarrollo 11200764Agencia Nacional de Investigación y Desarrollo 1180185Agencia Nacional de Investigación y Desarrollo 1201173Millennium Institute of Immunology and Immunotherapy P09/016-F, ICN09_016UCEN grants CIP2019007
6 · The paper itself

Abstract

backgroundExtended-spectrum beta-lactamase (ESBL) and carbapenemase (KPC METHODOLOGY: Bimetallic Re(I)-based compounds, PSRe-µL1 and PSRe-µL2, were tested in aPDI and compared with a Ru(II)-based PS positive control. The ability of PSRe-µL1 and PSRe-µL2 to inhibit

resultsAt a minimum dose of 4 µg/mL, both the PSRe-µL1 and PSRe-µL2 significantly inhibited in 3log

conclusionCompounds PSRe-µL1 and PSRe-µL2 produce an effective and synergistic aPDI effect on KPC

Indexed as

antibiotic synergyKlebsiella pneumoniaemulti-drug resistancephotodynamic therapy

Identifiers

PMID34834303
PMCPMC8621492
OpenAlexW3214511406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.