Evidence map›Paper›PMID 34834274›Full record

ArticlePharmaceutics2021

Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection.

Jiří Zeman, Sylvie Pavloková, David Vetchý, Adam Staňo, Zdeněk Moravec, Lukáš Matějovský, Vladimír Pitschmann

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jiří ZemanDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0002-7258-9390
Sylvie PavlokováDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0003-1414-2889
David VetchýDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, 612 00 Brno, Czech Republic.
Adam StaňoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, 612 00 Brno, Czech Republic.
Zdeněk MoravecDepartment of Chemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.ORCID 0000-0003-4377-3575
Lukáš MatějovskýFaculty of Environmental Technology, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic.ORCID 0000-0002-0248-4809
Vladimír PitschmannOritest Spol. s r.o., Čerčanská 640/30, 140 00 Prague, Czech Republic.
Masaryk University · CZOritest Group (Czechia) · CZUniversity of Chemistry and Technology, Prague · CZ

Funding

Ministerstvo Vnitra České Republiky VI20192022172
6 · The paper itself

Abstract

Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area (SSA), which should allow better adsorption of toxic substances and detection reagents. In this study, a magnesium aluminometasilicate with high SSA was utilized along with various concentrations of volatile substances (menthol, camphor and ammonium bicarbonate) to increase further the carrier SSA after their sublimation. The samples were evaluated in terms of physicochemical parameters, their morphology was assessed by scanning electron microscopy, and the Brunauer-Emmett-Teller (BET) method was utilized to measure SSA. The samples were then impregnated with a detection reagent o-phenylenediamine-pyronine and tested with diphosgene. Only samples prepared using menthol or camphor were found to show red fluorescence under the UV light in addition to the eye-visible red-violet color. This allowed the detection of diphosgene/phosgene at a concentration of only 0.1 mg/m

Indexed as

BET methodchemical warfare agentdetection tubeextrusionmetasilicatephosgeneporous pelletsspheronizationvolatile substance

Identifiers

PMID34834274
PMCPMC8622269
OpenAlexW3209365011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.