Evidence map›Paper›PMID 34834235›Full record

ArticlePharmaceutics2021

Intrapericardial Delivery of APA-Microcapsules as Promising Stem Cell Therapy Carriers in an Experimental Acute Myocardial Infarction Model.

Claudia Báez-Díaz, Virginia Blanco-Blázquez, Francisco Miguel Sánchez-Margallo, Esther López, Helena Martín, Albert Espona-Noguera, Javier G Casado, Jesús Ciriza, José Luis Pedraz, Verónica Crisóstomo

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Claudia Báez-DíazCIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Virginia Blanco-BlázquezCIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Francisco Miguel Sánchez-MargalloCIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-2138-988X
Esther LópezFundación Centro de Cirugía de Mínima Invasión Jesús Usón, 10071 Cáceres, Spain.ORCID 0000-0002-5051-5913
Helena MartínFundación Centro de Cirugía de Mínima Invasión Jesús Usón, 10071 Cáceres, Spain.
Albert Espona-NogueraCentro de Investigaciones y Estudios Avanzados Lucio Lascaray (CIEA), Laboratorio de Desarrollo y Evaluación de Medicamentos, 01006 Vitoria Gasteiz, Spain.ORCID 0000-0002-3681-030X
Javier G CasadoImmunology Unit-Institute of Molecular Pathology Biomarkers, Veterinary Faculty, University of Extremadura, 10003 Cáceres, Spain.
Jesús CirizaCIBER bbn, Instituto de Salud Carlos III, 28029 Madrid, Spain.
José Luis PedrazCentro de Investigaciones y Estudios Avanzados Lucio Lascaray (CIEA), Laboratorio de Desarrollo y Evaluación de Medicamentos, 01006 Vitoria Gasteiz, Spain.ORCID 0000-0002-3938-2267
Verónica CrisóstomoCIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-1740-7029

Funding

Agencia Estatal de Investigación PID2019-107329RA-C22/AEI/10.13039/501100011033Consejería de Economía, Ciencia y Agenda Digital, Junta de Extremadura GR18199Consejería de Economía, Ciencia y Agenda Digital, Junta de Extremadura IB20184Consejería de Economía, Ciencia y Agenda Digital, Junta de Extremadura IB20191Instituto de Salud Carlos III CB16/11/00494Instituto de Salud Carlos III PI20/00247Instituto de Salud Carlos III Sara Borrell CD19/00048
6 · The paper itself

Abstract

The administration of cardiosphere-derived cells (CDCs) after acute myocardial infarction (AMI) is very promising. CDC encapsulation in alginate-poly-l-lysine-alginate (APA) could increase cell survival and adherence. The intrapericardial (IP) approach potentially achieves high concentrations of the therapeutic agent in the infarcted area. We aimed to evaluate IP therapy using a saline vehicle as a control (CON), a dose of 30 × 10

Indexed as

AMIAPACDCsintrapericardialmicrocapsulesswine

Identifiers

PMID34834235
PMCPMC8626005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.