Evidence map›Paper›PMID 34834218›Full record

ReviewPharmaceutics2021

2D Nanosheets-A New Class of Therapeutic Formulations against Cancer.

Ravichandran Manisekaran, René García-Contreras, Aruna-Devi Rasu Chettiar, Paloma Serrano-Díaz, Christian Andrea Lopez-Ayuso, Ma Concepción Arenas-Arrocena, Genoveva Hernández-Padrón, Luz M López-Marín, Laura Susana Acosta-Torres

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Advances in Biologically Applicable Graphene-Based 2D Nanomaterials.International journal of molecular sciences · 2022
    Review
  9. Engineering the Surface of TiPharmaceutics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ravichandran ManisekaranLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.ORCID 0000-0002-2934-0717
René García-ContrerasLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.ORCID 0000-0003-3504-5519
Aruna-Devi Rasu ChettiarFacultad de Química, Materiales-Energía, Universidad Autónoma de Querétaro, Santiago de Querétaro 76010, Mexico.
Paloma Serrano-DíazLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.
Christian Andrea Lopez-AyusoLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.
Ma Concepción Arenas-ArrocenaLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.ORCID 0000-0002-8463-9340
Genoveva Hernández-PadrónCentro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Juriquilla 76230, Mexico.
Luz M López-MarínCentro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Juriquilla 76230, Mexico.ORCID 0000-0002-7503-6169
Laura Susana Acosta-TorresLaboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 37689, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers in cancer nanomedicine are exploring a revolutionary multifaceted carrier for treatment and diagnosis, resulting in the proposal of various drug cargos or "magic bullets" in this past decade. Even though different nano-based complexes are registered for clinical trials, very few products enter the final stages each year because of various issues. This prevents the formulations from entering the market and being accessible to patients. In the search for novel materials, the exploitation of 2D nanosheets, including but not limited to the highly acclaimed graphene, has created extensive interest for biomedical applications. A unique set of properties often characterize 2D materials, including semiconductivity, high surface area, and their chemical nature, which allow simple decoration and functionalization procedures, structures with high stability and targeting properties, vectors for controlled and sustained release of drugs, and materials for thermal-based therapies. This review discusses the challenges and opportunities of recently discovered 2D nanosheets for cancer therapeutics, with special attention paid to the most promising design technologies and their potential for clinical translation in the future.

Indexed as

2D materialblack phosphorusdrug deliveryLDHsMXenenanosheetstherapeuticstransition metal dichalcogenides

Identifiers

PMID34834218
PMCPMC8620729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.