Evidence map›Paper›PMID 34834171›Full record

ArticlePharmaceutics2021

Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia.

Chen-Hung Lee, Kuo-Sheng Liu, Julien George Roth, Kuo-Chun Hung, Yen-Wei Liu, Shin-Huei Wang, Chi-Ching Kuo, Shih-Jung Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chen-Hung LeeDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.ORCID 0000-0002-8392-8423
Kuo-Sheng LiuDepartment of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Julien George RothInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7560-3258
Kuo-Chun HungDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.ORCID 0000-0001-8655-3711
Yen-Wei LiuDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.
Shin-Huei WangDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.
Chi-Ching KuoResearch and Development Center of Smart Textile Technology, Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan.ORCID 0000-0002-1994-4664
Shih-Jung LiuDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0003-2083-4865
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Taipei University of Technology · TWStanford University · US

Funding

Chang Gung Memorial Hospital (CGMH-NTUT -2021-No.6) (C-H L. and C-C K.), and Chang Gung Memorial Hospital (CMRPG3J1281 and CMRPG3K1331) (C-H L.)National Science Council MOST 109-2314-B-182A-035-MY3 (C-H L.), MOST 109-2622-E-027-004 -CC3 and MOST 109-2221-E-027-114-MY3 (C-C K.))National Science Foundation Graduate Research Fellowship Program (J.G.R.) and the Stanford Smith Family Graduate Fellowship (J.G.R.) for their support under grant no. DGE-1656518
6 · The paper itself

Abstract

Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(d,l)-lactide-

Indexed as

controlled releasedrug-loaded nanofibersPLGAtelmisartan

Identifiers

PMID34834171
PMCPMC8623288
OpenAlexW3205443971

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.