Evidence map›Paper›PMID 34834167›Full record

ArticlePharmaceutics2021

[

Gaëlle Hugon, Sébastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Nature communications · 2025
    Observational
  4. Imaging quantitative changes in blood-brain barrier permeability using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Towards updated understanding of brain metastasis.American journal of cancer research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gaëlle HugonCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.
Sébastien GoutalCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.
Ambre DaubaCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.
Louise BreuilCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.
Benoit LarratCNRS, CEA, DRF/JOLIOT/NEUROSPIN/BAOBAB, Université Paris-Saclay, 91191 Gif-sur-Yvette, France.ORCID 0000-0003-1577-6293
Alexandra WinkelerCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.ORCID 0000-0003-3397-2570
Anthony NovellCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.ORCID 0000-0003-3649-0956
Nicolas TournierCEA, CNRS, Inserm, BioMaps, Université Paris-Saclay, 91401 Orsay, France.ORCID 0000-0002-0755-2030

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain. Translational and quantitative imaging techniques are needed to noninvasively monitor and optimize the impact of FUS on blood-brain barrier (BBB) permeability in vivo. Positron-emission tomography (PET) imaging using [

Indexed as

blood-brain barrierfocused ultrasoundintegrity markerpositron emission tomographysorbitol

Identifiers

PMID34834167
PMCPMC8621256

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.