Evidence map›Paper›PMID 34834156›Full record

ArticlePharmaceutics2021

Improving the Efficacy of Antimicrobials against Biofilm-Embedded Bacteria Using Bovine Hyaluronidase Azoximer (Longidaza

Elena Trizna, Diana Baidamshina, Anna Gorshkova, Valentin Drucker, Mikhail Bogachev, Anton Tikhonov, Airat Kayumov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Drug delivery strategies for antibiofilm therapy.Nature reviews. Microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elena TriznaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Diana BaidamshinaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Anna GorshkovaLimnological Institute of the Siberian Branch of the Russian Academy of Sciences, 664000 Irkutsk, Russia.
Valentin DruckerLimnological Institute of the Siberian Branch of the Russian Academy of Sciences, 664000 Irkutsk, Russia.
Mikhail BogachevBiomedical Engineering Research Centre, St. Petersburg Electrotechnical University, 197022 St. Petersburg, Russia.ORCID 0000-0002-0356-5651
Anton TikhonovNPO Petrovax Pharma LLC, 123112 Moscow, Russia.
Airat KayumovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0001-7195-1557
Kazan Federal University · RUSiberian Branch of the Russian Academy of Sciences · RUSaint Petersburg State Electrotechnical University · RU

Funding

Council for Grants of the President of the Russian Federation МК-3052.2021.1.4Russian Foundation for Basic Research 20-04-00247The Ministry of Education and Science of the Russian Federation 0279-2021-0015
6 · The paper itself

Abstract

While in a biofilm, bacteria are extremely resistant to both antimicrobials and the immune system, leading to the development of chronic infection. Here, we show that bovine hyaluronidase fused with a copolymer of 1,4-ethylenepiperazine N-oxide and (N-carboxymethyl) -1,4-ethylenepiperazinium bromide (Longidaza

Indexed as

bacterial biofilmsbovine hyaluronidase azoximer (Longidaza)enzymatic destruction of the biofilm

Identifiers

PMID34834156
PMCPMC8622991
OpenAlexW3209481935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.