Evidence map›Paper›PMID 34834106›Full record

ArticleMolecules (Basel, Switzerland)2021

Leucosceptoside A from Devil's Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes.

Ivanka K Koycheva, Liliya V Mihaylova, Monika N Todorova, Zhivka P Balcheva-Sivenova, Kalina Alipieva, Claudio Ferrante, Giustino Orlando, Milen I Georgiev

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. The Fight against Infection and Pain: Devil's Claw (Molecules (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ivanka K KoychevaDepartment Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
Liliya V MihaylovaDepartment Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-1690-1490
Monika N TodorovaDepartment Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
Zhivka P Balcheva-SivenovaDepartment Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
Kalina AlipievaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Claudio FerranteDepartment of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.ORCID 0000-0001-9431-9407
Giustino OrlandoDepartment of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.
Milen I GeorgievDepartment Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.ORCID 0000-0001-5248-6135
Bulgarian Academy of Sciences · BGUniversity of Chieti-Pescara · IT

Funding

European Commission PlantaSYST-739582
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin condition characterized by abnormal keratinocyte proliferation and differentiation that is accompanied with dysregulated immune response and abnormal vascularization. Devil's claw (

Indexed as

Anti-Inflammatory AgentsGlucosidesPsoriasisCell LineHarpagophytumHumansInflammationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAnti-Inflammatory AgentsGlucosidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktdevil’s clawinflammationin silico dockingkeratinocytesleucosceptoside Apsoriasisverbascoside

Identifiers

PMID34834106
PMCPMC8618597
OpenAlexW3215919032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.