Evidence map›Paper›PMID 34834099›Full record

ArticleMolecules (Basel, Switzerland)2021

The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust,

Victoria L Luck, David P Richards, Ashif Y Shaikh, Henrik Franzyk, Ian R Mellor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. (-)-Adaline from theMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Victoria L LuckSchool of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
David P RichardsSchool of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Ashif Y ShaikhDepartment of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.
Henrik FranzykDepartment of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, 2100 Copenhagen, Denmark.ORCID 0000-0002-2822-1927
Ian R MellorSchool of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.ORCID 0000-0002-8332-5155
University of Nottingham · GBUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the polyamine and amino acid (tyrosine) moieties of philanthotoxin-343 (PhTX-343) were investigated for their effects on the antagonism of nicotinic acetylcholine receptors (nAChRs) isolated from the locust (

Indexed as

AcetylcholineAmino AcidsAnimalsGrasshoppersInsect ProteinsNicotinic AntagonistsPhenolsPolyaminesProtein ConformationReceptors, NicotinicTyrosineAcetylcholineAmino AcidsInsect ProteinsNicotinic AntagonistsPhenolsphilanthotoxin 343phTX 12PolyaminesReceptors, NicotinicTyrosinelocustneuronnicotinic acetylcholine receptorpatch-clampphilanthotoxin

Identifiers

PMID34834099
PMCPMC8622278
OpenAlexW3217376134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.