Evidence map›Paper›PMID 34834083›Full record

ArticleMolecules (Basel, Switzerland)2021

A Pharmacokinetic Study of Ephedrine and Pseudoephedrine after Oral Administration of Ojeok-San by Validated LC-MS/MS Method in Human Plasma.

Sooyoung Lee, Wang-Seob Shim, Heejo Yoo, Sanghee Choi, Jiyoung Yoon, Kwang-Young Lee, Eun-Kyoung Chung, Byung-Cheol Lee, Sung-Vin Yim, Bo-Hyung Kim and 1 more

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sooyoung LeeDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-4800-4348
Wang-Seob ShimKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-0903-1386
Heejo YooKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
Sanghee ChoiDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Jiyoung YoonDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-6861-6600
Kwang-Young LeeDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
Eun-Kyoung ChungDepartment of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-9200-2799
Byung-Cheol LeeDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0003-2209-6229
Sung-Vin YimDepartment of Clinical Pharmacology and Therapeutics, Kyung Hee University Medical Center, Seoul 02447, Korea.ORCID 0000-0003-4393-800X
Bo-Hyung KimDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0003-3233-2918
Kyung-Tae LeeDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-3141-3727
Kyung Hee University · KR

Funding

Korea Health Industry Development Institute HF20C0022
6 · The paper itself

Abstract

A sensitive and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) system was developed and fully validated for the simultaneous determination of ephedrine and pseudoephedrine in human plasma after oral administration of the herbal prescription Ojeok-san (OJS); 2-phenylethylamine was used as the internal standard (IS). Both compounds presented a linear calibration curve (

Indexed as

EphedrinePseudoephedrineTandem Mass SpectrometryAdministration, OralChromatography, LiquidFemaleHumansMalePlant ExtractsRepublic of KoreaEphedrineojeok-sanPlant ExtractsPseudoephedrinebioanalytical method validationephedrinehealthy volunteersliquid chromatography-tandem mass spectrometrypharmacokineticspseudoephedrine

Identifiers

PMID34834083
PMCPMC8622238
OpenAlexW3215258244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.