Evidence map›Paper›PMID 34834072›Full record

ArticleMolecules (Basel, Switzerland)2021

Structural Effects of Disease-Related Mutations in Actin-Binding Period 3 of Tropomyosin.

Balaganesh Kuruba, Marta Kaczmarek, Małgorzata Kęsik-Brodacka, Magdalena Fojutowska, Małgorzata Śliwinska, Alla S Kostyukova, Joanna Moraczewska

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Balaganesh KurubaGene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163, USA.
Marta KaczmarekDepartment of Biochemistry and Cell Biology, Faculty of Biological Sciences, Kazimierz Wielki University, 85-671 Bydgoszcz, Poland.
Małgorzata Kęsik-BrodackaNational Medicines Institute, 00-725 Warsaw, Poland.
Magdalena FojutowskaDepartment of Biochemistry and Cell Biology, Faculty of Biological Sciences, Kazimierz Wielki University, 85-671 Bydgoszcz, Poland.
Małgorzata ŚliwinskaDepartment of Biochemistry and Cell Biology, Faculty of Biological Sciences, Kazimierz Wielki University, 85-671 Bydgoszcz, Poland.
Alla S KostyukovaGene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163, USA.
Joanna MoraczewskaDepartment of Biochemistry and Cell Biology, Faculty of Biological Sciences, Kazimierz Wielki University, 85-671 Bydgoszcz, Poland.ORCID 0000-0003-4518-3843

Funding

REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASER01GM120137 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GALKIN, VITOLD, GREGORIO, CAROL C · 2017 to 2024
$4.0M
National Institutes of Health Clinical Center GM120137National Science Center 2014/15/B/NZ1/01017NIGMS NIH HHS R01 GM120137Polish Minister of Science and Higher Education , under the program "Regional Initiative of Excellence" in 2019-2022 008/RID/2018/19
6 · The paper itself

Abstract

Tropomyosin (Tpm) is an actin-binding coiled-coil protein. In muscle, it regulates contractions in a troponin/Ca

Indexed as

Molecular Dynamics SimulationMutation, MissenseActinsAmino Acid SubstitutionHumansMuscular DiseasesTropomyosinActinsTPM1 protein, humanTPM3 protein, humanTropomyosincardiomyopathycircular dichroismcoiled coilcongenital myopathymolecular dynamics simulationpeptidepoint mutationsstabilitytropomyosin

Identifiers

PMID34834072
PMCPMC8622905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.