Evidence map›Paper›PMID 34834047›Full record

ArticleMolecules (Basel, Switzerland)2021

Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl

Ekaterina Kots, Derek M Shore, Harel Weinstein

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular determinants of pH sensing in the proton-activated chloride channel.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ekaterina KotsDepartment of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA.
Derek M ShoreDepartment of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA.ORCID 0000-0002-8845-6285
Harel WeinsteinDepartment of Physiology and Biophysics, Weill Cornell Medical School, New York, NY 10065, USA.ORCID 0000-0003-3473-9818
Cornell University · US

Funding

Ca2+-dependent lipid scrambling and ion transport by TMEM16 proteinsR01GM106717 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ACCARDI, ALESSIO, WEINSTEIN, HAREL · 2014 to 2023
$4.3M
National Science Foundation NSF #1740990NIH HHS R01GM106717
6 · The paper itself

Abstract

Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl

Indexed as

AntiportersEscherichia coliEscherichia coli ProteinsHydrogen-Ion ConcentrationMicroscopy, Atomic ForceMolecular Dynamics SimulationProtein ConformationProtonsAntiportersCLC-ec1 protein, E coliEscherichia coli ProteinsProtonsCLC transportershigh-resolution atomic force microscopy (HR-AFM)molecular dynamics (MD) simulationsnet charge conservation protocolpH-dependent activityprotonation state representations

Identifiers

PMID34834047
PMCPMC8625536
OpenAlexW3211841948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.