Evidence map›Paper›PMID 34834018›Full record

ArticleMolecules (Basel, Switzerland)2021

miR-370-3p Regulates Adipogenesis through Targeting Mknk1.

Peiwen Zhang, Xinrong Li, Shunhua Zhang, Shuang Wu, Qian Xiao, Yang Gu, Xinyu Guo, Xutao Lin, Lei Chen, Ye Zhao and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Peiwen ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0003-4637-4094
Xinrong LiCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Shunhua ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Shuang WuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Qian XiaoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Yang GuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Xinyu GuoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Xutao LinCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lei ChenCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Ye ZhaoCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lili NiuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Guoqing TangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Yanzhi JiangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Linyuan ShenCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-6072-3268
Li ZhuCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive fat accumulation can lead to obesity, diabetes, hyperlipidemia, atherosclerosis, and other diseases. MicroRNAs are a class of microRNAs that regulate gene expression and are highly conserved in function among species. microRNAs have been shown to act as regulatory factors to inhibit fat accumulation in the body. We found that miR-370-3p was expressed at lower levels in the fat mass of mice on a high-fat diet than in mice on a normal control diet. Furthermore, our data showed that the overexpression of miR-370-3p significantly suppressed the mRNA expression levels of adipogenic markers. Thus, miR-370-3p overexpression reduced lipid accumulation. Conversely, the inhibition of miR-370-3p suppressed 3T3-L1 preadipocyte proliferation and promoted preadipocyte differentiation. In addition, Mknk1, a target gene of miR-370-3p, plays an opposing role in preadipocyte proliferation and differentiation. Moreover, consistent results from in vitro as well as in vivo experiments suggest that the inhibition of fat accumulation by miR-370-3p may result from the inhibition of saturated fatty acids that promote the accumulation of polyunsaturated fatty acids. In conclusion, these results suggest that miR-370-3p plays an important role in adipogenesis and fatty acid metabolism through the regulation of Mknk1.

Indexed as

Adipogenesis3T3-L1 CellsAdipocytesAnimalsCell DifferentiationCell ProliferationHeLa CellsHumansIntracellular Signaling Peptides and ProteinsMiceMicroRNAsProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN370 microRNA, humanMIRN370 microRNA, mouseMKNK1 protein, humanMknk1 protein, mouseProtein Serine-Threonine Kinasesadipogenesisdifferentiationfatty acid compositionmiR-370-3pproliferation

Identifiers

PMID34834018
PMCPMC8619113
OpenAlexW3211996811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.