Evidence map›Paper›PMID 34834016›Full record

ArticleMolecules (Basel, Switzerland)2021

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative.

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares, Cleonice Creusa Dos Santos, Luciano Vasconcellos Pacheco, Ivanilson Pimenta Santos, Tatiana Barbosa Dos Santos Magalhães, Milena Botelho Pereira Soares, Elisalva Teixeira Guimarães and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  3. Curcumin in treatment of hematological cancers: Promises and challenges.Journal of traditional and complementary medicine · 2024
    Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Saul Vislei Simões da SilvaDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Orlando Maia BarbozaDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Jéssica Teles SouzaLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador 40231-300, BA, Brazil.
Érica Novaes SoaresLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador 40231-300, BA, Brazil.
Cleonice Creusa Dos SantosLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador 40231-300, BA, Brazil.
Luciano Vasconcellos PachecoDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Ivanilson Pimenta SantosGonçalo Moniz Institute, FIOCRUZ, Salvador 40296-710, BA, Brazil.
Tatiana Barbosa Dos Santos MagalhãesDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Institute, FIOCRUZ, Salvador 40296-710, BA, Brazil.
Elisalva Teixeira GuimarãesDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Cássio Santana MeiraDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Silvia Lima CostaLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-8975-3871
Victor Diógenes Amaral da SilvaLaboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador 40231-300, BA, Brazil.
Lourenço Luís Botelho de SantanaDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Aníbal de Freitas Santos JúniorDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.ORCID 0000-0002-3022-0771
Universidade do Estado da Bahia · BRUniversidade Federal da Bahia · BRFundação Oswaldo Cruz · BRServiço Nacional de Aprendizagem Industrial · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural modification in Q by acetylation, thus, obtaining the quercetin pentaacetate (Q5) analogue, in order to investigate the biological potentials (antioxidant, antileishmania, anti-inflammatory and cytotoxicity activities) in cell cultures. Q5 was characterized by FTIR,

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsAntiprotozoal AgentsAcetylationAnimalsHep G2 CellsHL-60 CellsHumansMiceMice, Inbred BALB CQuercetinAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsAntiprotozoal AgentsQuercetinquercetin pentaacetateanti-inflammatoryantileishmaniaantioxidantcytotoxicity activityquercetinquercetin pentaacetatesynthesis

Identifiers

PMID34834016
PMCPMC8623808
OpenAlexW3213544100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.