Evidence map›Paper›PMID 34833886›Full record

ArticleMolecules (Basel, Switzerland)2021

Discovery of New Ginsenol-Like Compounds with High Antiviral Activity.

Aleksandrina S Volobueva, Olga I Yarovaya, Marina V Kireeva, Sophia S Borisevich, Kseniya S Kovaleva, Iliya Ya Mainagashev, Yuri V Gatilov, Margarita G Ilyina, Vladimir V Zarubaev, Nariman F Salakhutdinov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Aleksandrina S VolobuevaLaboratory of Experimental Virology Pasteur Institute of Epidemiology and Microbiology, 14 Mira Str., 197101 St. Petersburg, Russia.
Olga I YarovayaDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-2333-4893
Marina V KireevaBiology Department, St. Petersburg State University, 7/9 Universitetskaya Nab., 199034 St. Petersburg, Russia.
Sophia S BorisevichLaboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia.
Kseniya S KovalevaDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0003-2357-6873
Iliya Ya MainagashevDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-4910-1772
Yuri V GatilovDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-4128-7293
Margarita G IlyinaLaboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia.ORCID 0000-0002-5552-9353
Vladimir V ZarubaevLaboratory of Experimental Virology Pasteur Institute of Epidemiology and Microbiology, 14 Mira Str., 197101 St. Petersburg, Russia.ORCID 0000-0002-5224-3771
Nariman F SalakhutdinovDepartment of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.
Novosibirsk Institute of Organic Chemistry · RUSaint Petersburg Pasteur Institute · RUUfa Institute of Chemistry · RUSt Petersburg University · RU

Funding

Ministry of Science and Higher Education 075-15-2020-777
6 · The paper itself

Abstract

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.

Indexed as

AmidesAnimalsAntiviral AgentsCell LineChinaDrug Resistance, ViralFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMiceMice, Inbred BALB CNeuraminidaseOrthomyxoviridae InfectionsSesquiterpenesAmidesAntiviral AgentsginsenolNeuraminidaseSesquiterpenesantiviral agentGinsamideGinsenolinfluenzamolecular modelingresistancesurface protein

Identifiers

PMID34833886
PMCPMC8619001
OpenAlexW3212583477

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.