ArticleMolecules (Basel, Switzerland)2021
Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin.
Dongjin Leng, Yong Sheng, Hengyu Wang, Jianhua Wei, Yixin Ou, Zixin Deng, Linquan Bai, Qianjin Kang
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors at 1 institution in 1 country.
Dongjin LengState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yong ShengState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Hengyu WangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Jianhua WeiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-4900-8631 Yixin OuState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Zixin DengState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Linquan BaiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-3269-9747 Qianjin KangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-4894-0056 Shanghai Jiao Tong University · CN
Funding
National Key Research and Development Program of China 2019YFA0905400National Natural Science Foundation of China 31770034, 21661140002 and 31830104Shanghai Municipal Council of Science and Technology 19ZR1475600
6 · The paper itselfAbstract
Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for assembling the pharmaceutically unprecedented chemical scaffold. Herein, we focused on the determination of acyl carrier protein (ACP)-dependent modification steps and identification of the protein-protein interactions between MmcB (ACP) with the partners in the early-stage biosynthesis of mitomycin C. Based on the initial genetic manipulation consisting of gene disruption and complementation experiments, genes
Indexed as
Acyl Carrier ProteinAmino Acid SequenceAminobenzoatesAnti-Bacterial AgentsChinaEscherichia coliEscherichia coli ProteinsHydroxybenzoatesMitomycinMitomycinsProtein Interaction MappingProtein Interaction MapsStreptomycesAcyl Carrier ProteinAminobenzoatesAnti-Bacterial AgentsEscherichia coli ProteinsHydroxybenzoatesMitomycinMitomycinsmitosaneacyl carrier proteinantitumorglycosyltransferasemitomycinprotein–protein interactionsreductase
Identifiers
PMID34833880
PMCPMC8621148
OpenAlexW3213167585
What OpenQuestion holds
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LicenceCC BY
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