Evidence map›Paper›PMID 34833757›Full record

ArticleSensors (Basel, Switzerland)2021

Redox Sensor Array with 23.5-μm Resolution for Real-Time Imaging of Hydrogen Peroxide and Glutamate Based on Charge-Transfer-Type Potentiometric Sensor.

Tatsuya Iwata, Yuki Okumura, Koichi Okumura, Tomoko Horio, Hideo Doi, Kazuhiro Takahashi, Kazuaki Sawada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatsuya IwataDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.ORCID 0000-0002-9846-297X
Yuki OkumuraDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Koichi OkumuraDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Tomoko HorioDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Hideo DoiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Kazuhiro TakahashiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Kazuaki SawadaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 4418580, Japan.
Toyohashi University of Technology · JP

Funding

Japan Science and Technology Agency JPMJCR14G2Japan Science and Technology Agency JPMJOP1834Japan Society for the Promotion of Science JP18H03778
6 · The paper itself

Abstract

Towards clarifying the spatio-temporal neurotransmitter distribution, potentiometric redox sensor arrays with 23.5-µm resolution were fabricated. The sensor array based on a charge-transfer-type potentiometric sensor comprises 128×128 pixels with gold electrodes deposited on the surface of pixels. The sensor output corresponding to the interfacial potential of the electrode changed logarithmically with the mixture ratio of K3Fe(CN)6 and K4Fe(CN)6, where the redox sensitivity reached 49.9 mV/dec. By employing hydrogen peroxidase as an enzyme and ferrocene as an electron mediator, the sensing characteristics for hydrogen peroxide (H2O2) were investigated. The analyses of the sensing characteristics revealed that the sensitivity was about 44.7 mV/dec., comparable to the redox sensitivity, while the limit of detection (LOD) was achieved to be 1 µM. Furthermore, the oxidation state of the electron mediator can be the key to further lowering the LOD. Then, by immobilizing oxidizing enzyme for H2O2 and glutamate oxidase, glutamate (Glu) measurements were conducted. As a result, similar sensitivity and LOD to those of H2O2 were obtained. Finally, the real-time distribution of 1 µM Glu was visualized, demonstrating the feasibility of our device as a high-resolution bioimaging technique.

Indexed as

Biosensing TechniquesHydrogen PeroxideElectrodesGlutamic AcidGoldOxidation-ReductionPotentiometryGlutamic AcidGoldHydrogen PeroxidebioimagingglutamateH2O2potentiometryredox sensor array

Identifiers

PMID34833757
PMCPMC8618362
OpenAlexW3215927570

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.