Evidence map›Paper›PMID 34833660›Full record

ArticleSensors (Basel, Switzerland)2021

Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation.

Bertram Richter, Zachary Mace, Megan E Hays, Santosh Adhikari, Huy Q Pham, Robert J Sclabassi, Benedict Kolber, Saigopalakrishna S Yerneni, Phil Campbell, Boyle Cheng and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Bertram RichterSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Zachary MaceSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Megan E HaysDepartment of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA.
Santosh AdhikariDepartment of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA.
Huy Q PhamDepartment of Biomedical Engineering, North Dakota State University, Fargo, ND 58102, USA.ORCID 0000-0002-0973-3222
Robert J SclabassiSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Benedict KolberDepartment of Neuroscience, University of Texas at Dallas, Richardson, TX 75080, USA.
Saigopalakrishna S YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15217, USA.
Phil CampbellDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15217, USA.
Boyle ChengSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Nestor TomyczSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Donald M WhitingSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Trung Q LeDepartment of Industrial and Manufacturing Engineering, North Dakota State University, Fargo, ND 58102, USA.ORCID 0000-0002-4169-9941
Toby L NelsonDepartment of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA.
Saadyah AverickSystem Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Allegheny Health Network · USOklahoma State University · USCarnegie Mellon University · USNorth Dakota State University · USThe University of Texas at Dallas · US

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Advancements in electrode technologies to both stimulate and record the central nervous system's electrical activities are enabling significant improvements in both the understanding and treatment of different neurological diseases. However, the current neural recording and stimulating electrodes are metallic, requiring invasive and damaging methods to interface with neural tissue. These electrodes may also degrade, resulting in additional invasive procedures. Furthermore, metal electrodes may cause nerve damage due to their inherent rigidity. This paper demonstrates that novel electrically conductive organic fibers (ECFs) can be used for direct nerve stimulation. The ECFs were prepared using a standard polyester material as the structural base, with a carbon nanotube ink applied to the surface as the electrical conductor. We report on three experiments: the first one to characterize the conductive properties of the ECFs; the second one to investigate the fiber cytotoxic properties in vitro; and the third one to demonstrate the utility of the ECF for direct nerve stimulation in an in vivo rodent model.

Indexed as

Nanotubes, CarbonElectric ConductivityElectric StimulationElectrodesNanotubes, Carbonconductive sensing fiberelectrical probenerve stimulation

Identifiers

PMID34833660
PMCPMC8619502
OpenAlexW3213104859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.