ArticlePolymers2021
Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Biosynthesis of ecofriendly antibacterial nanoparticles with healing effects in a murine diabetic skin infection model.Scientific reports · 2026Article
- Dietary Supplements in Public Health: Benefits, Risks, and Emerging Gel/Hydrogel Delivery Systems.Gels (Basel, Switzerland) · 2026Review
- Therapeutic potential of Aloe vera in diabetes mellitus treatment: an update.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Review
- Collagen-Inducing Compounds from Chihuahuan Desert Plants for Potential Skin Bioink 3D Printing Applications: A Narrative Review.Journal of functional biomaterials · 2026Review
- Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.Polymers · 2025Review
- PEGylated chitosan xerogels for localized periodontal therapy: design, characterization, and drug release.Scientific reports · 2025Article
- Optimization of Film-Dressings Containing Herbal Extracts for Wound Care-A Quality by Design Approach.Gels (Basel, Switzerland) · 2025Article
- In vitro characterization of potential botanicals to reduce infection and improve the rate of wound healing in humans and canines.BMC complementary medicine and therapies · 2025Article
- Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant.Current pharmaceutical biotechnology · 2025Review
- HarnessingPharmaceutics · 2024Review
- Efficacy of a novel combination of aloe vera gel and pineapple extracts in improving post-extraction pain and healing: A Randomized Controlled Trial.Journal of clinical and experimental dentistry · 2024Article
- Transforming Medicinal Oil into Advanced Gel: An Update on Advancements.Gels (Basel, Switzerland) · 2024Review
- Review
- Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds.International journal of molecular sciences · 2023Article
- Evidence for Natural Products as Alternative Wound-Healing Therapies.Biomolecules · 2023Review
- The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants.Life (Basel, Switzerland) · 2023Review
- Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control.Polymers · 2022Article
- Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications.International journal of biomaterials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.