Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice.

Chengqing Hu, Jiangcheng Shi, Yujing Chi, Jichun Yang, Qinghua Cui

Open access · goldAbstract read

In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact, top 85% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chengqing HuCenter for Noncoding RNA Medicine, Department of Physiology and Pathophysiology, Department of Biomedical Informatics, MOE Key Laboratory of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.ORCID 0000-0002-0461-9148

Jiangcheng ShiCenter for Noncoding RNA Medicine, Department of Physiology and Pathophysiology, Department of Biomedical Informatics, MOE Key Laboratory of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.ORCID 0000-0001-9934-4556

Yujing ChiDepartment of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0002-4069-9093

Jichun YangCenter for Noncoding RNA Medicine, Department of Physiology and Pathophysiology, Department of Biomedical Informatics, MOE Key Laboratory of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.

Qinghua CuiCenter for Noncoding RNA Medicine, Department of Physiology and Pathophysiology, Department of Biomedical Informatics, MOE Key Laboratory of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.

Peking University · CN

Funding

National Key R&D Program；PKU-Baidu Fund；Natural Science Foundation of China；Peking University Basic Research Program 2020YFC2004704；2019BD014；81970440, 62025102, 81921001；BMU2020JC001

6 · The paper itself

Abstract

The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show lower expression levels in the left testis than in the right testis in healthy mice using bioinformatics modeling of miRNA-sequencing data, suggesting that the Y:X ratio could be unbalanced between the left testis and the right testis. We further reveal that the Y:X ratio is significantly elevated in the left testis but balanced in the right testis using flow cytometry. This study represents the first time the biased Y:X ratio in the left testis but not in the right testis is revealed.

Indexed as

sex chromosomeX-chromosome-bearing spermY-chromosome-bearing sperm

Identifiers

PMID34833095

DOI10.3390/life11111219

PMCPMC8621333

OpenAlexW3214106229

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.