Evidence map›Paper›PMID 34833020›Full record

ArticleLife (Basel, Switzerland)2021

The Impact of Dehydration and Hyperthermia on Circulatory Glutathione Metabolism after Exercise in the Heat with Insights into the Role of Erythrocytes.

Denise de Melo-Marins, Juliano Boufleur Farinha, Franccesco Pinto Boeno, Alexandra Ferreira Vieira, Samuel Vargas Munhoz, Gabriela Cristina Dos Santos, Mauricio Krause, Orlando Laitano, Alvaro Reischak-Oliveira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. New Advances in Human Thermophysiology.Life (Basel, Switzerland) · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Denise de Melo-MarinsSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.
Juliano Boufleur FarinhaSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.
Franccesco Pinto BoenoSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.ORCID 0000-0001-7729-7015
Alexandra Ferreira VieiraSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.
Samuel Vargas MunhozSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.
Gabriela Cristina Dos SantosSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.
Mauricio KrauseLaboratory of Inflammation, Metabolism and Exercise Research (LAPIMEX), Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, Brazil.ORCID 0000-0001-9814-742X
Orlando LaitanoDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0003-2768-1427
Alvaro Reischak-OliveiraSchool of Physical Education, Physical Therapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90040-060, Brazil.ORCID 0000-0003-4590-2991
Universidade Federal do Rio Grande do Sul · BRFlorida State University · US

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.199844/2018-00
6 · The paper itself

Abstract

backgroundReduced glutathione (GSH) is one of the main thiols involved in antioxidant defense. Changes in circulatory levels of GSH during exercise are associated with hyperthermia and dehydration. The mechanisms by which these alterations occur are not entirely known. We hypothesize that erythrocytes could be an important source of circulatory GSH during heat stress conditions. We performed two separate experiments to address this hypothesis.

methodsIn the first experiment, we sought to investigate the impact of exercise in the heat and dehydration on erythrocyte levels of GSH. A total of 10 men performed 60 min of cycling at 60% VO

resultsDehydration decreased circulatory GSH, regardless of ambient temperature (temperate and heat decreased 15.35% and 30.31%, respectively), resulting in an altered redox balance. Heat increased GSH levels in vitro.

conclusionOur data suggest that dehydration decreases circulatory GSH levels regardless of environmental temperature. In addition, in vitro data suggests that erythrocytes may contribute to the release of GSH during exposure to heat stress.

Indexed as

exerciseheathydrationoxidative stress

Identifiers

PMID34833020
PMCPMC8625141
OpenAlexW3210080223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.