ArticlePharmaceuticals (Basel, Switzerland)2021
Antiparasitic Effect of Stilbene and Terphenyl Compounds against
Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
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- A Review on the Immunological Response againstPathogens (Basel, Switzerland) · 2023Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite
methodsThis study evaluated the in vitro antiparasitic activity of a series of previously synthesized stilbene and terphenyl compounds in
resultsThe stilbene ST18 was the most potent compound of the series. It was slightly less active than Nifurtimox in epimastigotes but most active in intracellular amastigotes. Compared to Nifurtimox, it was markedly less cytotoxic when tested in vitro on normal cells. ST18 was able to induce a marked increase in parasites positive for Annexin V and monodansylcadaverine. Moreover, ST18 induced the activation, in infected macrophages, of caspase-1, a conserved enzyme that plays a major role in controlling parasitemia, host survival and the onset of the adaptive immune response in Trypanosoma infection.
conclusionsThe antiparasitic activity of ST18 together with its ability to activate caspase-1 in infected macrophages and its low toxicity toward normal cells makes this compound interesting for further clinical investigation.
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