Evidence map›Paper›PMID 34832958›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol.

Jaeuk Sim, Srinu Lanka, Jeong-Woong Jo, Chhabi Lal Chaudhary, Manjunatha Vishwanath, Chan-Hyun Jung, Young-Hee Lee, Eun-Yeong Kim, Young-Soo Kim, Soon-Sil Hyun and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Design, synthesis,Heliyon · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jaeuk SimCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Srinu LankaCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Jeong-Woong JoCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Chhabi Lal ChaudharyCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.ORCID 0000-0001-8890-7181
Manjunatha VishwanathCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Chan-Hyun JungCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Young-Hee LeeCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Eun-Yeong KimCollege of Pharmacy, Korea University, Sejong 30019, Korea.
Young-Soo KimCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Soon-Sil HyunCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.ORCID 0000-0002-3400-7353
Hee-Soon LeeCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.
Kiho LeeCollege of Pharmacy, Korea University, Sejong 30019, Korea.ORCID 0000-0001-6151-6543
Seung-Yong SeoGachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea.ORCID 0000-0002-2672-4707
Mayavan VijiCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.ORCID 0000-0001-7454-8229
Jae-Kyung JungCollege of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Korea.ORCID 0000-0002-0490-9663
Chungbuk National University · KRKorea University · KRGachon University · KR

Funding

National Research Foundation of Korea grants funded by the Korea Government (MSIT) MRC 2017R1A5A2015541, and 2020R1A2C1007346.
6 · The paper itself

Abstract

In continuation of studies for α-MSH stimulated melanogenesis inhibitors, we have evaluated the design, synthesis, and activity of a new series of chlorogenic acid (CGA) analogues comprising pyridine, pyrimidine, and diacyl derivatives. Among nineteen synthesized compounds, most of them (fifteen) exhibited better inhibitions of melanin formation in B16 melanoma cells. The results illustrated that a pyridine analogue

Indexed as

B16 melanoma cellschlorogenic acidpyridinepyrimidineα-MSH-stimulated melanogenesis

Identifiers

PMID34832958
PMCPMC8622415
OpenAlexW3211454973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.