ArticlePharmaceuticals (Basel, Switzerland)2021
Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering.
Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Rheology-Guided PHB/PBAT/MgO Nanocomposites for FDM Printing with Balanced Mechanical and Degradation Performance.ACS omega · 2026Article
- Polyhydroxybutyrate (PHB) production from halophiles: a comprehensive review.Bioresources and bioprocessing · 2026Review
- Development of PHB-based bio-nanocomposite films with enhanced bioactivity and cytocompatibility for alveolar bone regeneration.RSC advances · 2026Article
- Antibacterial bionanocomposite hydrogel based on hydroxyethyl cellulose, poly(vinyl alcohol), and montmorillonite clay as a scaffold for bone tissue engineering application.Scientific reports · 2025Article
- Review
- Poly(3-hydroxybutyrate)/Clay/Essential Oils Bionanocomposites Incorporating Biochar: Thermo-Mechanical and Antioxidant Properties.Polymers · 2025Article
- Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.RSC advances · 2024Review
- Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application.International journal of molecular sciences · 2024Review
- 3D Printed Piezoelectric BaTiOBioengineering (Basel, Switzerland) · 2024Article
- Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment.Current issues in molecular biology · 2024Review
- Effect of agarose/gelatin gel addition on the pro-angiogenic potential of polyhydroxybutyrate/chitosan scaffolds.Frontiers in cell and developmental biology · 2024Article
- Fabrication and properties of PLA/β-TCP scaffolds using liquid crystal display (LCD) photocuring 3D printing for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2024Article
- From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration.Burns & trauma · 2024Review
- ZnO Nanoparticles-Reinforced Chitosan-Xanthan Gum Blend Novel Film with Enhanced Properties and Degradability for Application in Food Packaging.ACS omega · 2023Article
- Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate.Polymers · 2023Article
- Novel Hydrophilic Oligomer-Crosslinked Gelatin-Based Hydrogels for Biomedical Applications.Gels (Basel, Switzerland) · 2023Article
- Article
- Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review.Materials (Basel, Switzerland) · 2023Review
- Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields.Pharmaceutics · 2023Review
- Influence of Cholesterol on the Regulation of Osteoblast Function.Metabolites · 2023Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.