Evidence map›Paper›PMID 34832919›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Synthesis of NIR-II Absorbing Gelatin Stabilized Gold Nanorods and Its Photothermal Therapy Application against Fibroblast Histiocytoma Cells.

Adewale Oladipo, Thabang Calvin Lebepe, Sundararajan Parani, Rodney Maluleke, Vuyelwa Ncapayi, Grace It Mwad Mbaz, Sandile Phinda Songca, Tetsuya Kodama, Oluwatobi Samuel Oluwafemi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Adewale OladipoDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.
Thabang Calvin LebepeDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.ORCID 0000-0002-6623-8519
Sundararajan ParaniDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.ORCID 0000-0001-6107-030X
Rodney MalulekeDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.
Vuyelwa NcapayiDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.
Grace It Mwad MbazDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.
Sandile Phinda SongcaDepartment of Chemistry, University of KwaZulu-Natal, Private Bag X 54001, Durban 4000, South Africa.ORCID 0000-0003-2522-5567
Tetsuya KodamaGraduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai 980-8575, Japan.ORCID 0000-0003-4727-9558
Oluwatobi Samuel OluwafemiDepartment of Chemical Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.ORCID 0000-0001-8964-5646
University of Johannesburg · ZATohoku University · JPUniversity of KwaZulu-Natal · ZA

Funding

JSPS KAKENHI 26242051 and 24650286National Research Foundation (NRF) South Africa 97982; 106060; 129290; 112867; 131237 and 98299
6 · The paper itself

Abstract

The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report a simple synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The optical and structural properties of the as-synthesized gelatin@Au-NRs were investigated by Zetasizer, Ultraviolet-Visible-Near Infrared (UV-Vis-NIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and Fourier transform infrared spectroscopy (FTIR). The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 ± 2.3 nm and 10 ± 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco's Modified Eagle's Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. An in vitro photothermal therapy study against KM-Luc/GFP showed that gelatin@Au-NRs effectively destroys the cancer cells.

Indexed as

cytotoxicitygelatingold nanorodsnear-infraredphotothermal therapystability

Identifiers

PMID34832919
PMCPMC8625232
OpenAlexW3213751350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.