Evidence map›Paper›PMID 34832911›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the

Helenita C Quadros, Aysun Çapcı, Lars Herrmann, Sarah D'Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudêncio, Svetlana B Tsogoeva and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  8. The Potentials ofInfection and drug resistance · 2023
    Review
  9. PfMDR1 Transport Rates Assessed in Intact IsolatedPharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Helenita C QuadrosInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Salvador 40296-710, Brazil.ORCID 0000-0002-7191-4809
Aysun ÇapcıOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany.
Lars HerrmannOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany.
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9241-9762
Diana FontinhaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0002-0046-648X
Raquel AzevedoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0003-2896-7224
Wilmer VillarrealGrupo de Química Inorgânica Medicinal e Reações Aplicadas, Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9030-1066
Miguel PrudêncioInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0003-1746-6029
Svetlana B TsogoevaOrganic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany.ORCID 0000-0003-4845-0951
Diogo R M MoreiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Salvador 40296-710, Brazil.ORCID 0000-0003-3323-4404
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Lisbon · PTFundação Oswaldo Cruz · BRUniversity of Milan · ITUniversidade Federal do Rio Grande do Sul · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Deutsche Forschungsgemeinschaft TS87/17-1; TS87/23-1Fondazione Cariplo 2017-0846Fundação de Amparo à Pesquisa do Estado da Bahia APP0088/2016Fundação para a Ciência e Tecnologia PTDC-SAU-INF- 29550-2017Ministero degli Affari Esteri e della Cooperazione Internazionale Progetti di grande rilevanza, grant number 00949-2018Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2015.4JRJPP_004)National Council for Scientific and Technological Development 305732/2019-6
6 · The paper itself

Abstract

A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of

Indexed as

artemisininhemozoinheterobivalenthybridsmalariaPlasmodium

Identifiers

PMID34832911
PMCPMC8620906
OpenAlexW3212058642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.