Evidence map›Paper›PMID 34832895›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors.

Momen R Fareed, Mai E Shoman, Mohammed I A Hamed, Mohamed Badr, Hanin A Bogari, Sameh S Elhady, Tarek S Ibrahim, Gamal El-Din A Abuo-Rahma, Taha F S Ali

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Novel furo[2,3-RSC medicinal chemistry · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Momen R FareedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Mai E ShomanDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0001-6837-5093
Mohammed I A HamedDepartment of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum 63514, Egypt.
Mohamed BadrDepartment of Biochemistry, Faculty of Pharmacy, Menoufia University, Shibin el Kom 32511, Egypt.
Hanin A BogariDepartment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Sameh S ElhadyDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3799-0581
Tarek S IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-3049-4617
Gamal El-Din A Abuo-RahmaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Taha F S AliDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-8881-0408
King Abdulaziz University · SAMinia University · EGDeraya UniversityFayoum University · EGMenoufia University · EG

Funding

Deanship of Scientific Research (DSR), King Abdulaziz University, DF-451-166-1441
6 · The paper itself

Abstract

A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound

Indexed as

antiproliferativecasein kinaseEGFR kinase inhibitorsoindolestubulin polymerization inhibitors

Identifiers

PMID34832895
PMCPMC8620390
OpenAlexW3209325055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.