Evidence map›Paper›PMID 34832881›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives.

Paulina Strzyga-Łach, Alicja Chrzanowska, Katarzyna Podsadni, Anna Bielenica

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Special Issue "Anticancer Drugs 2021".Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paulina Strzyga-ŁachChair and Department of Biochemistry, Medical University of Warsaw, 02-097 Warszawa, Poland.ORCID 0000-0003-1830-2210
Alicja ChrzanowskaChair and Department of Biochemistry, Medical University of Warsaw, 02-097 Warszawa, Poland.
Katarzyna PodsadniChair and Department of Biochemistry, Medical University of Warsaw, 02-097 Warszawa, Poland.
Anna BielenicaChair and Department of Biochemistry, Medical University of Warsaw, 02-097 Warszawa, Poland.ORCID 0000-0003-3269-9672
Medical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl)phenylthiourea analogs were synthesized, and their cytotoxicity was evaluated in vitro against the cell line panel. Compounds

Indexed as

apoptosiscytotoxic activityinterleukin-6thioureatrypan blue assay

Identifiers

PMID34832881
PMCPMC8623398
OpenAlexW3209924892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.