Evidence map›Paper›PMID 34832666›Full record

ReviewPathogens (Basel, Switzerland)2021

Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors.

Hugo Aguilar-Díaz, Rosa Estela Quiroz-Castañeda, Karina Salazar-Morales, Raquel Cossío-Bayúgar, Estefan Miranda-Miranda

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. A NovelMicroorganisms · 2023
    Article
  10. Article
  11. Differential Expression of Immune Genes in thePathogens (Basel, Switzerland) · 2022
    Article
  12. Advances in the Immunobiology of Parasitic Diseases.Pathogens (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hugo Aguilar-DíazUnidad de Artropodología, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico.ORCID 0000-0002-6497-6462
Rosa Estela Quiroz-CastañedaUnidad de Anaplasmosis, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico.ORCID 0000-0002-1099-2440
Karina Salazar-MoralesCentro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico.
Raquel Cossío-BayúgarUnidad de Artropodología, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico.
Estefan Miranda-MirandaUnidad de Artropodología, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad INIFAP, Jiutepec 62574, Mexico.ORCID 0000-0002-0464-3666
Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias · MXInstituto Nacional de Salud Pública · MX

Funding

Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Fondos Fiscales SIGI 13512934133
6 · The paper itself

Abstract

Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines.

Indexed as

anti-tick vaccinescattle diseasesextracellular trapsExtracellular Traps Formation (ETosis)Neutrophils Extracellular Traps Formation (NETosis)Rhipicephalus microplustick immune system

Identifiers

PMID34832666
PMCPMC8621429
OpenAlexW3214950030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.