Evidence map›Paper›PMID 34832660›Full record

ArticlePathogens (Basel, Switzerland)2021

Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing.

Shaorong Chen, Dongmei Zhang, Alexandria-Jade Roberts, Hsueh-Chung Lu, Carolyn L Cannon, Qing-Ming Qin, Paul de Figueiredo

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shaorong ChenDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Dongmei ZhangDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Alexandria-Jade RobertsDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Hsueh-Chung LuDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Carolyn L CannonDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-2491-0389
Qing-Ming QinDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-1723-6867
Paul de FigueiredoDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Texas A&M Health Science Center · US

Funding

NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
Defense Advanced Research Projects Agency HR001118A0025-FoF-FP-006National Science Foundation DBI 1532188, NSF0854684NIH HHS R21AI139738-01A1, 1 R01AI141607-01A1, 1R21GM132705-01;the Bill Melinda Gates Foundation and the Texas A&M Clinical Science Translational Research Institute Pilot Grant CSTR2016-1
6 · The paper itself

Abstract

Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on

Indexed as

antibioticsbacterial pathogenshost complement systemhost immune systemmultidrug resistant bacteriaprotease neutrophil elastase

Identifiers

PMID34832660
PMCPMC8618517
OpenAlexW3213637918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.