Evidence map›Paper›PMID 34832564›Full record

ReviewPathogens (Basel, Switzerland)2021

Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form.

Annа Malkova, Igor Kudryavtsev, Anna Starshinova, Dmitry Kudlay, Yulia Zinchenko, Anzhela Glushkova, Piotr Yablonskiy, Yehuda Shoenfeld

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Long-Term Consequences of Asymptomatic SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
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  19. Long COVID: An approach to clinical assessment and management in primary care.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annа MalkovaMedical Department, St-Petersburg State University, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-6008-1354
Igor KudryavtsevDepartment of Immunology, Institution of Experimental Medicine, 197376 Saint-Petersburg, Russia.
Anna StarshinovaAlmazov National Medical Research Centre, 197341 Saint-Petersburg, Russia.
Dmitry KudlayMedical Department, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.ORCID 0000-0003-1878-4467
Yulia ZinchenkoSt. Petersburg Research Institute of Phthisiopulmonology, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-6273-4304
Anzhela GlushkovaV.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, 192019 Saint-Petersburg, Russia.
Piotr YablonskiyMedical Department, St-Petersburg State University, 199034 Saint-Petersburg, Russia.
Yehuda ShoenfeldMedical Department, St-Petersburg State University, 199034 Saint-Petersburg, Russia.

Funding

Federal Almazov North-West Medical Research Centre
6 · The paper itself

Abstract

Post COVID-19 Syndrome (PCS) is a complex of various symptoms developing a month or more after the acute phase of the disease. The cases of PCS development among patients with asymptomatic/mild forms are frequently reported; however, the pathogenesis of PCS in this group of patients is still not completely clear. The publications about COVID-19 which were published in online databases from December 2019 to September 2021 are analyzed in this review. According to the analysis, PCS develops on average in 30-60% of patients, mainly among women. Fatigue, shortness of breath, cough, and anosmia were reported as the most common symptoms. The possible association between the described PCS symptoms and brain damage was revealed. We assume the possibility of an alternative course of COVID-19, which develops in genetically predisposed individuals with a stronger immune response, in which it predominantly affects the cells of the nervous system, possibly with the presence of an autoimmune component, which might have similarity with chronic fatigue syndrome or autoimmune disautonomia. Thus, the gender (female) and the presence of anosmia during an asymptomatic or mild course of the disease can be predictive factors for the development of PCS, which can be caused by autoimmune damage to neurons, glia, and cerebral vessels.

Indexed as

anosmiaasymptomaticautoimmuneautoimmune dysautonomiaCOVID-19fatiguemildMyalgic Encephalomyelitis/Chronic Fatigue SyndromePost COVID-19 Syndrome

Identifiers

PMID34832564
PMCPMC8620929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.