Evidence map›Paper›PMID 34832553›Full record

ReviewPathogens (Basel, Switzerland)2021

The Flo Adhesin Family.

Ronnie G Willaert, Yeseren Kayacan, Bart Devreese

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cell Wall Proteome ofPathogens (Basel, Switzerland) · 2026
    Article
  6. Microbiology spectrum · 2025
    Article
  7. Comparative Genomics and Characterisation of the Role ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Functional Redundancy inResearch square · 2024
    Article
  10. Functional Redundancy inbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Sticking to the Subject: Multifunctionality in Microbial Adhesins.Journal of fungi (Basel, Switzerland) · 2023
    Review
  18. Study of the binding of ΔFN3.1 fragments of theMicrobiome research reports · 2023
    Article
  19. Adhesion as a Focus in Trichoderma-Root Interactions.Journal of fungi (Basel, Switzerland) · 2022
    Review
  20. Structure and Conservation of Amyloid Spines From theFrontiers in molecular biosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Ronnie G WillaertResearch Group Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium.ORCID 0000-0002-5400-7019
Yeseren KayacanResearch Group Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium.
Bart DevreeseAlliance Research Group VUB-UGent NanoMicrobiology (NAMI), 1050 Brussels, Belgium.ORCID 0000-0002-9764-2581
Vrije Universiteit Brussel · BE

Funding

Belgian Federal Science Policy Office PRODEX Flumias NanomotionBelgian Federal Science Policy Office PRODEX Yeast BioreactorEuropean Space Agency PRODEX Flumias NanomotionEuropean Space Agency PRODEX Yeast BioreactorResearch Foundation - Flanders 310030L_197946Research Foundation - Flanders I002620
6 · The paper itself

Abstract

The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.

Indexed as

abiotic surface adhesionadhesin architectureadhesin structureCandida glabrataFlo adhesin familyhost-pathogen interactionpathogenic yeastsSaccharomyces cerevisiae

Identifiers

PMID34832553
PMCPMC8621652
OpenAlexW3210105333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.