ReviewPathogens (Basel, Switzerland)2021
A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines.
Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells.Seminars in immunopathology · 2022Pooled it
- Solitary ulcer at the mons pubis in a heterosexual male patient.Wiener medizinische Wochenschrift (1946) · 2026Article
- Vaginal microbiomes and their pertinent social context: a microbial ecological review proffering AMR-STI acquisition and emergence.Biology of sex differences · 2026Review
- Visual clues - dermatological manifestations of sexually transmitted infections in men.Nature reviews. Urology · 2026Review
- Evaluating syphilis transmission among MSM population: a mathematical model for reinfection, two-stage treatment, and treatment failure.Frontiers in public health · 2026Article
- A rare case of concurrent longitudinally extensive myelitis and retinal vein occlusion.IDCases · 2026Article
- Epidemiological trends of syphilis and the analysis of knowledge and attitudes of future healthcare professionals on its prevention in the autonomous Province of Vojvodina, Serbia.Journal of health, population, and nutrition · 2025Article
- Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: aJournal of clinical microbiology · 2025Article
- Coinfection of syphilis and HIV: epidemiological evaluation at the Dermatology Department in Lodz, Poland.Postepy dermatologii i alergologii · 2025Article
- The Role of Traditional and Reverse Algorithms in the Diagnosis of Syphilis in HIV-Infected Individuals: A Case Study on Istanbul.Diagnostics (Basel, Switzerland) · 2025Article
- Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review.Current pharmaceutical biotechnology · 2025Review
- The impact of HBV, HCV, or syphilis infections on embryo and pregnancy outcomes in couples undergoing IVF treatment: a matched cohort study.Human reproduction open · 2025Article
- Atypical Dermatological Manifestations of Syphilis in Advanced HIV: A Case-Based Narrative Review.Mediterranean journal of hematology and infectious diseases · 2025Article
- Multiplex Loop-Mediated Isothermal Amplification Coupled Lateral Flow Assay for Point-of-Care Detection of Syphilis.Indian journal of microbiology · 2024Article
- Finger nodules with a papulovesicular hands and feet eruption: a complicated human Orf virus infection.BMC infectious diseases · 2024Article
- Article
- Molecular Characterization of Genital and Extragenital Lesions With the PlexPCR VHS Assay in Patients Diagnosed With Syphilis.Open forum infectious diseases · 2023Article
- Exposure toMicroorganisms · 2023Article
- Viruses, bacteria and parasites: infection of the male genital tract and fertility.Basic and clinical andrology · 2023Review
- Three cases of neurosyphilis diagnosed in the 21st century: A case report.Experimental and therapeutic medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2021 the scientific community's efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.