Evidence map›Paper›PMID 34832326›Full record

ArticleMaterials (Basel, Switzerland)2021

A Fluorescence Kinetic-Based Aptasensor Employing Stilbene Isomerization for Detection of Thrombin.

Xinling Zeng, Qing Zhou, Liyan Wang, Xiaoxian Zhu, Kuiyan Cui, Xinsheng Peng, Terry W J Steele, Huizhi Chen, Hui Xu, Yubin Zhou

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Xinling ZengKey Laboratory of Chinese Medicinal Resource from Lingnan, Guangzhou University of Chinese Medicine, Ministry of Education, Guangzhou 510006, China.
Qing ZhouKey Laboratory of Chinese Medicinal Resource from Lingnan, Guangzhou University of Chinese Medicine, Ministry of Education, Guangzhou 510006, China.
Liyan WangSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Xiaoxian ZhuSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Kuiyan CuiSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Xinsheng PengSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Terry W J SteeleSchool of Materials Science & Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Huizhi ChenSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Hui XuKey Laboratory of Chinese Medicinal Resource from Lingnan, Guangzhou University of Chinese Medicine, Ministry of Education, Guangzhou 510006, China.
Yubin ZhouSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, China.ORCID 0000-0002-6811-1239
Guangdong Medical College · CNGuangzhou University of Chinese Medicine · CNNanyang Technological University · SG

Funding

Funds for PhD Researchers of Guangdong Medical University in 2021 4SG21237GGuangdong Basic and Applied Basic Research Foundation 2019A1515111036Guangdong Basic and Applied Basic Research Foundation 2019A1515111112Guangdong Basic and Applied Basic Research Foundation 2021A1515011831Zhanjiang non-funded science and technology research project 2020B01127
6 · The paper itself

Abstract

It is important to detect thrombin due to its physiological and pathological roles, where rapid and simple analytical approaches are needed. In this study, an aptasensor based on fluorescence attenuation kinetics for the detection of thrombin is presented, which incorporates the features of stilbene and aptamer. We designed and synthesized an aptasensor by one-step coupling of stilbene compound and aptamer, which employed the adaptive binding of the aptamer with thrombin to cause a change in stilbene fluorescence attenuation kinetics. The sensor realized detection of thrombin by monitoring the variation in apparent fluorescence attenuation rate constant (

Indexed as

aptamerbiosensorsfluorescencekinetic modephotoisomerizationthrombin

Identifiers

PMID34832326
PMCPMC8624160
OpenAlexW3213342115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.