Evidence map›Paper›PMID 34832035›Full record

ArticleMembranes2021

In Vivo Secretion of β-Lactamase-Carrying Outer Membrane Vesicles as a Mechanism of β-Lactam Therapy Failure.

Martina Bielaszewska, Ondřej Daniel, Otakar Nyč, Alexander Mellmann

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. How social is social resistance?Essays in biochemistry · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. [Research progress on the mechanism of -lactam resistance in group AZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  10. Review
  11. Review
  12. The biogenesis of β-lactamase enzymes.Microbiology (Reading, England) · 2022
    Review
  13. Article
  14. microLife · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Martina BielaszewskaCentre for Epidemiology and Microbiology, National Institute of Public Health, 100 00 Prague, Czech Republic.ORCID 0000-0002-1226-7066
Ondřej DanielCentre for Epidemiology and Microbiology, National Institute of Public Health, 100 00 Prague, Czech Republic.ORCID 0000-0002-0404-6589
Otakar NyčInstitute of Medical Microbiology, University Hospital Motol, 150 06 Prague, Czech Republic.
Alexander MellmannInstitute for Hygiene, University Hospital Münster, 48149 Münster, Germany.ORCID 0000-0002-0649-5185
Charles University · CZNational Institute of Public Health · CZUniversity Hospital in Motol · CZUniversity Hospital Münster · DE

Funding

Deutsche Forschungsgemeinschaft (DFG) 194468054 - SFB 1009, B04Ministry of Health NIPH 75010330
6 · The paper itself

Abstract

Outer membrane vesicles carrying β-lactamase (βLOMVs) protect bacteria against β-lactam antibiotics under experimental conditions, but their protective role during a patient's treatment leading to the therapy failure is unknown. We investigated the role of βLOMVs in amoxicillin therapy failure in a patient with group A

Indexed as

amoxicillin therapy failureGAS protectiongroup A Streptococcus pyogenes (GAS)Haemophilus influenzaein vivo secretionpharyngotonsillitisβ-lactamase-carrying outer membrane vesicles

Identifiers

PMID34832035
PMCPMC8625792
OpenAlexW3210821605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.