ArticleInternational journal of environmental research and public health2021
Down Syndrome in Brazil: Occurrence and Associated Factors.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Cognitive Predictors of Adaptive Behaviour in Children With Down Syndrome: A Systematic Review.Journal of applied research in intellectual disabilities : JARID · 2026Pooled it
- Tooth wear prevalence in individuals with Down syndrome: a systematic review.Clinical oral investigations · 2023Pooled it
- Parental and grandparental age in relation to Down syndrome risk and congenital heart disease in affected children: a case-control study in Peru.European journal of pediatrics · 2026Article
- Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross-sectional study.Journal of periodontology · 2026Article
- Caregiver Concerns for Children and Adolescents With Down Syndrome: A Cross-Sectional Study in Brazil.Child: care, health and development · 2026Article
- Obstructive sleep apnea in adults with Down syndrome: body composition, metabolic profile and cognitive status.Clinics (Sao Paulo, Brazil) · 2026Article
- Prevalence of Functional Constipation in Children with Down Syndrome: A Study Conducted at a General Pediatrics Service.Biomedicines · 2026Article
- Scientific production on health inequalities using the Brazilian Information System on Live Births: a scoping review.Cadernos de saude publica · 2026Article
- Follow-up of a 10-year period (2010-2020) of Down syndrome in Brazil.Brazilian oral research · 2025Article
- Observational
- Down syndrome and postoperative hemodynamics in patients undergoing surgery for congenital cardiac communications.Scientific reports · 2024Article
- (In)Fertility in the Down syndrome.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Population-specific facial traits and diagnosis accuracy of genetic and rare diseases in an admixed Colombian population.Scientific reports · 2023Article
- Epidemiology of birth defects in a national hospital-based birth defect surveillance spot in Southern Jiangsu, China, 2014-2018.Frontiers in medicine · 2023Article
- Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil.Emerging infectious diseases · 2023Article
- Health Policies for Rare Disease Patients: A Scoping Review.International journal of environmental research and public health · 2022Article
- Completeness and Consistency of Epidemiological Variables from Hospital-Based Cancer Registries in a Brazilian State.International journal of environmental research and public health · 2022Article
- Recurring violence against adolescents: an analysis of notifications.Revista latino-americana de enfermagem · 2022Article
- Use of family history taking for hereditary neoplastic syndromes screening in primary health care: A systematic review protocol.PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDown syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality.
methodsA retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson's chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%.
resultsWe observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (
conclusionsWomen aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.