Evidence map›Paper›PMID 34831486›Full record

ArticleCells2021

Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds.

Wan-Hua Tsai, Chia-Hsuan Chou, Tsuei-Yin Huang, Hui-Ling Wang, Peng-Ju Chien, Wen-Wei Chang, Hsueh-Te Lee

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
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  7. Review
  8. Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026
    Review
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  12. Article
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  17. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  18. Article
  19. [Research progress on the mechanisms of probiotics promoting wound healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wan-Hua TsaiResearch and Development Department, GenMont Biotech Incorporation, Tainan 741014, Taiwan.
Chia-Hsuan ChouResearch and Development Department, GenMont Biotech Incorporation, Tainan 741014, Taiwan.
Tsuei-Yin HuangResearch and Development Department, GenMont Biotech Incorporation, Tainan 741014, Taiwan.
Hui-Ling WangSchool of Biomedical Sciences, Chung Shan Medical University, Taichung 402306, Taiwan.
Peng-Ju ChienSchool of Biomedical Sciences, Chung Shan Medical University, Taichung 402306, Taiwan.
Wen-Wei ChangSchool of Biomedical Sciences, Chung Shan Medical University, Taichung 402306, Taiwan.ORCID 0000-0003-2283-1377
Hsueh-Te LeeInstitute of Anatomy & Cell Biology, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.ORCID 0000-0002-9152-2618
GenMont Biotech (Taiwan) · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

GenMont Biotech Incorporation, Tainan, Taiwan. E105N0139
6 · The paper itself

Abstract

Probiotics are defined as microorganisms with beneficial health effects when consumed by humans, being applied mainly to improve allergic or intestinal diseases. Due to the increasing resistance of pathogens to antibiotics, the abuse of antibiotics becomes inefficient in the skin and in systemic infections, and probiotics may also provide the protective effect for repairing the healing of infected cutaneous wounds. Here we selected two Lactobacillus strains,

Indexed as

Hot TemperatureWound HealingActinsAnimalsCell LineCell WallDisease Models, AnimalFemaleFibroblastsFibrosisHumansLactobacillusLipopolysaccharidesMaleMatrix Metalloproteinase 1MiceActa2 protein, mouseActinsLipopolysaccharideslipoteichoic acidMatrix Metalloproteinase 1Smad ProteinsTeichoic AcidsTransforming Growth Factor betaheat-killed probioticsLactobacilluslipoteichoic acidL. paracaseiL. plantarumskin wound healing

Identifiers

PMID34831486
PMCPMC8625647
OpenAlexW3217776610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.