Observational studyCells2021
A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory
Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph
Observational study in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03760484 (Serial Fecal Microbiota Transplant), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serial Fecal Microbiota Transplant (FMT) Plus Fidaxomicin in the Treatment of Severe or Fulminant Clostridium Difficile Infection, With Detailed Characterization in Microbiota, Metabolomics and Host Immune Response
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Multi-omics time-series analysis in microbiome research: a systematic review.Briefings in bioinformatics · 2025Pooled it
- Dynamics in Circulating Immune Cell Subsets After Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.Clinical and translational gastroenterology · 2026Trial
- Trial
- Distinct T and innate-like lymphocyte reprogramming following lyophilized fecal microbiota transplantation in recurrentGut microbes · 2026Article
- Review
- Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence.Aging cell · 2025Article
- Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing.Aging cell · 2025Article
- Overview of current detection methods and microRNA potential inWorld journal of gastroenterology · 2023Review
- Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection.Cell host & microbe · 2023Review
- The leaky gut and the gut microbiome in sepsis - targets in research and treatment.Clinical science (London, England : 1979) · 2023Article
- Immunological mechanisms of fecal microbiota transplantation in recurrentWorld journal of gastroenterology · 2022Review
- The interplay betweenFrontiers in cellular and infection microbiology · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 9 institutions in 5 countries.
Tanya M MonaghanNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, UK.
Niharika A DuggalMRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-4459-4632
Elisa RosatiInstitute of Clinical Molecular Biology, Universitätsklinikum Schleswig-Holstein, Christian-Albrecht University of Kiel, 24105 Kiel, Germany.ORCID 0000-0002-2635-6422
Ruth GriffinNottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0002-0269-059X
Jamie HughesSynthetic Biology Research Centre, The University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0001-6045-4053
Brandi RoachDivision of Gastroenterology, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.
David Y YangDivision of Gastroenterology, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.
Christopher WangDivision of Gastroenterology, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.
Karen WongDivision of Gastroenterology, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.
Lynora SaxingerDivision of Infectious Diseases, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.
Maja Pučić-BakovićGlycoscience Research Laboratory, Genos Ltd., Borongajska cesta 83H, 10000 Zagreb, Croatia.
Frano VučkovićGlycoscience Research Laboratory, Genos Ltd., Borongajska cesta 83H, 10000 Zagreb, Croatia.
Filip KlicekGlycoscience Research Laboratory, Genos Ltd., Borongajska cesta 83H, 10000 Zagreb, Croatia.ORCID 0000-0002-6245-8880
Gordan LaucGlycoscience Research Laboratory, Genos Ltd., Borongajska cesta 83H, 10000 Zagreb, Croatia.
Paddy TigheSchool of Life Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
Benjamin H MullishDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-6300-3100
Jesus Miguens BlancoDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Julie A K McDonaldDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-0739-6047
Julian R MarchesiDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-7994-5239
Ning XueSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham NG7 2UH, UK.
Tania DottoriniSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham NG7 2UH, UK.
Animesh AcharjeeCollege of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-2735-7010
Andre FrankeInstitute of Clinical Molecular Biology, Universitätsklinikum Schleswig-Holstein, Christian-Albrecht University of Kiel, 24105 Kiel, Germany.
Yingrui LiShenzhen Digital Life Institute, Shenzhen 518016, China.
Gane Ka-Shu WongDepartment of Biological Sciences, Department of Medicine, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Christos PolytarchouDepartment of Biosciences, John van Geest Cancer Research Centre, Centre for Health Aging and Understanding Disease, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Tung On YauDepartment of Biosciences, John van Geest Cancer Research Centre, Centre for Health Aging and Understanding Disease, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.ORCID 0000-0002-3283-0370
Niki ChristodoulouDepartment of Biosciences, John van Geest Cancer Research Centre, Centre for Health Aging and Understanding Disease, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Maria HatziapostolouDepartment of Biosciences, John van Geest Cancer Research Centre, Centre for Health Aging and Understanding Disease, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Minkun WangShenzhen Digital Life Institute, Shenzhen 518016, China.
Lindsey A RussellDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0001-8634-0775
Dina H KaoDivision of Gastroenterology, Department of Medicine, University of Alberta; Edmonton, Alberta, AB T6G 2G3, Canada.ORCID 0000-0002-6096-0586
University of Alberta · CAUniversity of Nottingham · GBImperial College London · GBNottingham Trent University · GBGenos (Croatia) · HRChristian-Albrechts-Universität zu Kiel · DEUniversity of Birmingham · GBMcMaster University · CAUniversity of Zagreb · HR
Funding
Medical Research Council MC_PC_12025Medical Research Council MR/R000875/1University of Alberta Hospital Foundation ZI418
Abstract
Fecal microbiota transplantation (FMT) is highly effective in recurrent
Indexed as
Fecal Microbiota TransplantationAgedAged, 80 and overAnimalsAntibodies, NeutralizingBacterial ToxinsChlorocebus aethiopsClostridium InfectionsCluster AnalysisFecesFemaleGastrointestinal MicrobiomeGenomicsHumansImmunosenescenceMaleAntibodies, NeutralizingBacterial ToxinsClostridium difficile lethal toxin BReceptors, Antigen, T-CellClostridioides difficilefecal microbiota transplantationhost-microbial interactionsimmunosenescencesystems biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT03760484ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.