Evidence map›Paper›PMID 34831339›Full record

ArticleCells2021

Phagocyte Chemoattraction Is Induced through the Mcp-1-Ccr2 Axis during Efferocytosis.

Sang-Ah Lee, Deokhwan Kim, Chanhyuk Min, Byeongjin Moon, Juyeon Lee, Hyunji Moon, Susumin Yang, Chang Sup Lee, Gwangrog Lee, Daeho Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sang-Ah LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-0860-3274
Deokhwan KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-6900-3870
Chanhyuk MinSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0001-8898-7898
Byeongjin MoonSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0001-9424-3270
Juyeon LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Hyunji MoonSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Susumin YangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-1634-5527
Chang Sup LeeCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Korea.
Gwangrog LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Daeho ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-2824-490X
Gwangju Institute of Science and Technology · KRGyeongsang National University · KR

Funding

National Research Foundation of Korea 2019R1A2C1006480National Research Foundation of Korea 2019R1A4A1028802
6 · The paper itself

Abstract

Apoptotic cells generated during development and for tissue homeostasis are swiftly and continuously removed by phagocytes via a process called efferocytosis. Efficient efferocytosis can be achieved via transcriptional modulation in phagocytes that have engulfed apoptotic cells. However, such modulation and its effect on efferocytosis are not completely understood. Here, we report that phagocytes are recruited to apoptotic cells being cleared through the Mcp-1-Ccr2 axis, which facilitates clearance of apoptotic cells. We identified

Indexed as

ChemotaxisPhagocytosisSignal TransductionAcidsAnimalsApoptosisChemokine CCL2Culture Media, ConditionedLysosomesMiceMice, Inbred C57BLPhagocytesReceptors, CCR2AcidsCcl2 protein, mouseChemokine CCL2Culture Media, ConditionedReceptors, CCR2apoptotic cellsCcr2chemoattractionefferocytosisMcp-1migrationphagocytes

Identifiers

PMID34831339
PMCPMC8620886
OpenAlexW3214289702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.