Evidence map›Paper›PMID 34831326›Full record

ArticleCells2021

Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na

Nolan M Dvorak, Cynthia M Tapia, Timothy J Baumgartner, Jully Singh, Fernanda Laezza, Aditya K Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022
    Review
  3. Inhibition of the Akt/PKB Kinase Increases NaInternational journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nolan M DvorakDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-1280-9918
Cynthia M TapiaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Timothy J BaumgartnerDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Jully SinghDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Fernanda LaezzaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-1141-1852
Aditya K SinghDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
The University of Texas Medical Branch at Galveston · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Molecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Neurotoxicology of deltamethrin in the developing brainR01ES031823 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GREEN, THOMAS ARTHUR, LAEZZA, FERNANDA · 2020 to 2024
$2.8M
Predoctoral and Postdoctoral Training in Alzheimer's PathophysiologyT32AG067952 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAYED, RAKEZ · 2021 to 2025
$1.5M
NIA NIH HHS T32 AG067952NIEHS NIH HHS R01 ES031823NIGMS NIH HHS T32 GM008280NIH HHS T32 ES007254NIH HHS T32 GM008280NIMH NIH HHS R01 MH124351
6 · The paper itself

Abstract

Voltage-gated Na

Indexed as

Cell Cycle ProteinsFibroblast Growth FactorsHEK293 CellsHumansIon Channel GatingMacromolecular SubstancesMutationNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelProtein Kinase InhibitorsProtein-Tyrosine KinasesCell Cycle Proteinsfibroblast growth factor 14Fibroblast Growth FactorsMacromolecular SubstancesNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelProtein Kinase InhibitorsProtein-Tyrosine KinasesWEE1 protein, humanfibroblast growth factor 14 (FGF14)patch-clamp electrophysiologyvoltage-gated Na+ (Nav) channelsWee1 kinase

Identifiers

PMID34831326
PMCPMC8619224
OpenAlexW3214010716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.