Evidence map›Paper›PMID 34831288›Full record

ReviewCells2021

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer's, Related Tauopathies and Genetic Tauopathies.

Geraldine Zimmer-Bensch, Hans Zempel

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. "Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Observational
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Perinatal S-Adenosylmethionine Supplementation RepressesInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
  16. Role of DNMTs in the Brain.Advances in experimental medicine and biology · 2022
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Geraldine Zimmer-BenschFunctional Epigenetics in the Animal Model, Institute for Biology II, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-8894-8079
Hans ZempelInstitute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.ORCID 0000-0002-7510-3077
RWTH Aachen University · DEUniversity of Cologne · DE

Funding

Deutsche Forschungsgemeinschaft 368482240/GRK2416DFGDeutsche Forschungsgemeinschaft ZI1224/13-1Else-Kröner-Fresenius Stiftung 2019_A41Koeln Fortune Program / Faculty of Medicine, University of Cologne 475/2020
6 · The paper itself

Abstract

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults. All tauopathies share ectopic expression, mislocalization, or aggregation of the microtubule associated protein TAU, encoded by the

Indexed as

Alzheimer DiseaseAnimalsBiomarkersDNA MethylationEpigenesis, GeneticHumansNerve DegenerationTauopathiesBiomarkersAlzheimerDNA methylationepigeneticsMAPTneurodegenerationneurogenetic diseaseTAUtauopathy

Identifiers

PMID34831288
PMCPMC8624300
OpenAlexW3212067834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.