Evidence map›Paper›PMID 34831263›Full record

ArticleCells2021

Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling.

Franziska Reinhardt, Kira Beneke, Nefeli Grammatica Pavlidou, Lenard Conradi, Hermann Reichenspurner, Leif Hove-Madsen, Cristina E Molina

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Downregulation of L-type CaHeart rhythm · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Enhanced CaJACC. Clinical electrophysiology · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Echocardiographic evaluation of the right atrial size and function: Relevance for clinical practice.American heart journal plus : cardiology research and practice · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Franziska ReinhardtDepartment of Cardiovascular Surgery, University Heart & Vascular Center Hamburg UKE, 20251 Hamburg, Germany.
Kira BenekeGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20251 Hamburg, Germany.
Nefeli Grammatica PavlidouGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20251 Hamburg, Germany.
Lenard ConradiDepartment of Cardiovascular Surgery, University Heart & Vascular Center Hamburg UKE, 20251 Hamburg, Germany.
Hermann ReichenspurnerDepartment of Cardiovascular Surgery, University Heart & Vascular Center Hamburg UKE, 20251 Hamburg, Germany.
Leif Hove-MadsenBiomedical Research Institute Barcelona, IIBB-CSIC and IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.
Cristina E MolinaGerman Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20251 Hamburg, Germany.ORCID 0000-0003-3094-1568
Universität Hamburg · DEHospital de Sant Pau · ES

Funding

Deutsche Forschungsgemeinschaft ES 569/2-1Ministerio de Ciencia e Innovación PID2020-116927RB-C21
6 · The paper itself

Abstract

Both, the decreased L-type Ca

Indexed as

Calcium SignalingAdrenergic beta-AntagonistsAgedAnimalsAtrial FibrillationCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, L-TypeCarvedilolCyclic AMPCyclic AMP-Dependent Protein KinasesCytosolFemaleHumansMaleMiddle AgedAdrenergic beta-AntagonistsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, L-TypeCarvedilolCyclic AMPCyclic AMP-Dependent Protein KinasesReceptors, Adrenergic, betaatrial fibrillation (AF)cAMP-dependent regulationL-type calcium current (ICa,L)patch-clampprotein kinase A (PKA)transient inward current (ITI)

Identifiers

PMID34831263
PMCPMC8616167
OpenAlexW3214232730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.