ReviewCells2021
Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility.
Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Association between long-term and short-term exposure to outdoor air pollution and stillbirth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Small extracellular vesicles: connecting early life exposure outcomes to air pollution during pregnancy to early childhood health.Environmental health : a global access science source · 2025Pooled it
- Silent Harm: How Ambient Air Pollution Threatens Prenatal and Neonatal Health. A Systematic Review.Investigacion y educacion en enfermeria · 2025Pooled it
- Exposure to radon and ambient particle radioactivity during pregnancy and adverse maternal, fetal and perinatal outcomes: The current literature and potential mechanisms.Environmental research · 2024Pooled it
- Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.Molecular psychiatry · 2023Pooled it
- Prenatal PMNature communications · 2026Article
- Review
- DNA methylation in the placenta and household socioeconomic status: the SPAH study.Clinical epigenetics · 2026Article
- Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood.International journal of molecular sciences · 2026Review
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- Impact of Wildland Fire Smoke PMEnvironmental science & technology · 2026Article
- Maternal and perinatal risk factors for necrotizing enterocolitis.World journal of pediatric surgery · 2026Review
- Special Issue "Molecular Insights into the Developmental Origins of Health and Disease".International journal of molecular sciences · 2025Article
- Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes.Molecular and cellular biochemistry · 2025Review
- Appropriate Lifelong Circadian Rhythms Are Established During Infancy: A Narrative Review.Clocks & sleep · 2025Review
- Assessing ambient air pollution's effects on birth outcomes: a Scottish IVF cohort study (2010 -2018).Environmental health : a global access science source · 2025Article
- Industrial air pollution and newborn hearing screening failure.Journal of hazardous materials · 2025Article
- The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study.Scientific reports · 2025Article
- Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Journey Mapping of Chinese Women Undergoing Termination Due to Fetal Abnormalities: A Thematic Content Analysis Based on Social Media Diaries.International journal of women's health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero exposures influence fetal programming and health in later life. Throughout pregnancy, the placenta plays a central role in fetal programming; it regulates the in utero environment and acts as a gatekeeper for nutrient and waste exchange between the mother and the fetus. Maternal exposure to air pollution, including heavy metals, can reach the placenta, where they alter DNA methylation patterns, leading to changes in placental function and fetal reprogramming. This review explores the current knowledge on placental DNA methylation changes associated with prenatal air pollution (including heavy metals) exposure and highlights its effects on fetal development and disease susceptibility. Prenatal exposure to air pollution and heavy metals was associated with altered placental DNA methylation at the global and promoter regions of genes involved in biological processes such as energy metabolism, circadian rhythm, DNA repair, inflammation, cell differentiation, and organ development. The altered placental methylation of these genes was, in some studies, associated with adverse birth outcomes such as low birth weight, small for gestational age, and decreased head circumference. Moreover, few studies indicate that DNA methylation changes in the placenta were sex-specific, and infants born with altered placental DNA methylation patterns were predisposed to developing neurobehavioral abnormalities, cancer, and atopic dermatitis. These findings highlight the importance of more effective and stricter environmental and public health policies to reduce air pollution and protect human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.