Evidence map›Paper›PMID 34831242›Full record

ArticleCells2021

Adult Neural Stem Cells from Midbrain Periventricular Regions Show Limited Neurogenic Potential after Transplantation into the Hippocampal Neurogenic Niche.

Mareike Fauser, Kai F Loewenbrück, Johannes Rangnick, Moritz D Brandt, Andreas Hermann, Alexander Storch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Plant-derived exosomes extracted fromBioengineering & translational medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mareike FauserDepartment of Neurology, University of Rostock, Gehlsheimer Straße 20, 18147 Rostock, Germany.
Kai F LoewenbrückDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
Johannes RangnickDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
Moritz D BrandtDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
Andreas HermannDivision of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.ORCID 0000-0002-7364-7791
Alexander StorchDepartment of Neurology, University of Rostock, Gehlsheimer Straße 20, 18147 Rostock, Germany.
German Center for Neurodegenerative Diseases · DETechnische Universität Dresden · DEUniversity of Rostock · DE

Funding

Deutsche Forschungsgemeinschaft CRC 1270, project C04Deutsche Forschungsgemeinschaft CRC 1270, rotation position programDeutsche Forschungsgemeinschaft CRC 655, project A23Hermann und Lilly Schilling-Stiftung Research group "Translational Neurodegeneration Rostock"
6 · The paper itself

Abstract

The regulation of adult neural stem or progenitor cell (aNSC) proliferation and differentiation as an interplay of cell-intrinsic and local environmental cues remains in part unclear, impeding their role in putative regenerative therapies. aNSCs with all major properties of NSCs in vitro have been identified in a variety of brain regions beyond the classic neurogenic niches, including the caudal periventricular regions (PVRs) of the midbrain, though active neurogenesis is either limited or merely absent in these regions. To elucidate cell-intrinsic properties of aNSCs from various PVRs, we here examined the proliferation and early differentiation capacity of murine aNSCs from non-neurogenic midbrain PVRs (PVR

Indexed as

NeurogenesisStem Cell NicheAdult Stem CellsAnimalsCell DifferentiationCell ProliferationGraft SurvivalHippocampusMesencephalonMiceMice, Inbred C57BLMice, TransgenicNeural Stem CellsPhysical Conditioning, AnimalSOXB1 Transcription FactorsSOXB1 Transcription Factorsadult neural stem cellsadult neurogenesiscell transplantationdentate gyrusneurogenic nicheneuronal differentiationnon-neurogenic region

Identifiers

PMID34831242
PMCPMC8616334
OpenAlexW3210408986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.