Evidence map›Paper›PMID 34831232›Full record

ArticleCells2021

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production.

Lidia Karabon, Anna Andrzejczak, Lidia Ciszak, Anna Tomkiewicz, Aleksandra Szteblich, Agnieszka Bojarska-Junak, Jacek Roliński, Dariusz Wołowiec, Tomasz Wróbel, Agata Kosmaczewska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Aberrant Expression ofCancers · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. The association ofFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lidia KarabonLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.ORCID 0000-0001-8172-0971
Anna AndrzejczakLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.ORCID 0000-0001-6098-7554
Lidia CiszakLaboratory of Immunopathology, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.ORCID 0000-0002-5135-6336
Anna TomkiewiczLaboratory of Genetics and Epigenetics of Human Diseases, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.
Aleksandra SzteblichLaboratory of Immunopathology, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.
Agnieszka Bojarska-JunakDepartment of Clinical Immunology, Medical University of Lublin, ul. Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-2340-9442
Jacek RolińskiDepartment of Clinical Immunology, Medical University of Lublin, ul. Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-4841-6120
Dariusz WołowiecDepartment and Clinic of Hematology, Blood Neoplasms, and Bone Marrow Transplantation, Medical University, Wybrzeże Ludwika Pasteura 4, 50-367 Wroclaw, Poland.
Tomasz WróbelDepartment and Clinic of Hematology, Blood Neoplasms, and Bone Marrow Transplantation, Medical University, Wybrzeże Ludwika Pasteura 4, 50-367 Wroclaw, Poland.
Agata KosmaczewskaLaboratory of Immunopathology, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigl 12 Str., 53-114 Wroclaw, Poland.ORCID 0000-0002-3805-9476
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLWroclaw Medical University · PLMedical University of Lublin · PL

Funding

Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences grant no. 6/2019-2020 for statutory activityMedical University of Lublin grant no. DS 458 and DS 460Wrocław Medical University Sub.C140.21.014 for statutory activity
6 · The paper itself

Abstract

In our previous study, while chronic lymphocytic leukemia (CLL) cases showed higher levels of B and T lymphocyte attenuator (BTLA) mRNA compared to controls, lower BTLA protein expression was observed in cases compared to controls. Hence we hypothesize that micro RNA (miR) 155-5p regulates BTLA expression in CLL. In line with earlier data, expression of BTLA mRNA and miR-155-5p is elevated in CLL (

Indexed as

Epigenesis, GeneticGene Expression Regulation, LeukemicAgedBase SequenceCell Line, TumorCell ProliferationFemaleHumansInterleukin-4Ki-67 AntigenLeukemia, Lymphocytic, Chronic, B-CellMaleMicroRNAsReceptors, ImmunologicRNA, MessengerBTLA protein, humanInterleukin-4Ki-67 AntigenMicroRNAsMIRN155 microRNA, humanReceptors, ImmunologicRNA, MessengerBTLACLLepigenetic regulationIL-4miR-155-5pproliferation

Identifiers

PMID34831232
PMCPMC8616199
OpenAlexW3208250347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.