Evidence map›Paper›PMID 34831229›Full record

ArticleCells2021

Mesenchymal Stem Cell Induced Foxp3(+) Tregs Suppress Effector T Cells and Protect against Retinal Ischemic Injury.

Mona Agrawal, Pratheepa Kumari Rasiah, Amandeep Bajwa, Johnson Rajasingh, Rajashekhar Gangaraju

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mona AgrawalDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Pratheepa Kumari RasiahDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-6649-2680
Amandeep BajwaJames D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0517-8871
Johnson RajasinghDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-6172-4083
Rajashekhar GangarajuDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-6664-8286
University of Tennessee Health Science Center · US

Funding

Vascular and Neuronal Repair with Adipose Stromal Cells in RetinopathyR01EY023427 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GANGARAJU, RAJASHEKHAR · 2013 to 2017
$1.8M
Mitochondrial Therapy for Kidney InjuryR01DK117183 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BAJWA, AMANDEEP · 2018 to 2022
$1.7M
scaRNA Modified Induced Pluripotent Stem Cell-Derived Cardiomyocytes or Exosomes Therapy for Chronic Ischemic Cardiomyopathy PatientsR01HL141345 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, RAJASINGH · 2019 to 2022
$1.5M
NEI NIH HHS EY023427NHLBI NIH HHS R01 HL141345NIDDK NIH HHS R01 DK117183
6 · The paper itself

Abstract

Mesenchymal stem/stromal cells (MSC) are well known for immunomodulation; however, the mechanisms involved in their benefits in the ischemic retina are unknown. This study tested the hypothesis that MSC induces upregulation of transcription factor forkhead box protein P3 (Foxp3) in T cells to elicit immune modulation, and thus, protect against retinal damage. Induced MSCs (iMSCs) were generated by differentiating the induced pluripotent stem cells (iPSC) derived from urinary epithelial cells through a noninsertional reprogramming approach. In in-vitro cultures, iMSC transferred mitochondria to immune cells via F-actin nanotubes significantly increased oxygen consumption rate (OCR) for basal respiration and ATP production, suppressed effector T cells, and promoted differentiation of CD4+CD25+ T regulatory cells (Tregs) in coculture with mouse splenocytes. In in-vivo studies, iMSCs transplanted in ischemia-reperfusion (I/R) injured eye significantly increased Foxp3+ Tregs in the retina compared to that of saline-injected I/R eyes. Furthermore, iMSC injected I/R eyes significantly decreased retinal inflammation as evidenced by reduced gene expression of

Indexed as

Adipose TissueAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteB-LymphocytesCD69 AntigensCell DifferentiationCell LineForkhead Transcription FactorsHumansInflammationIschemiaLectins, C-TypeMesenchymal Stem CellsMiceMice, Inbred C57BLAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensForkhead Transcription FactorsFoxp3 protein, mouseLectins, C-TypeCD4+CD25+inflammationiPSCmitochondriaretinopathy

Identifiers

PMID34831229
PMCPMC8616393
OpenAlexW3209147302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.