Evidence map›Paper›PMID 34831205›Full record

ReviewCells2021

Rho GTPases in Skeletal Muscle Development and Homeostasis.

Sonia Rodríguez-Fdez, Xosé R Bustelo

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Sonia Rodríguez-FdezMolecular Mechanisms of Cancer Program, Centro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-5369-2969
Xosé R BusteloMolecular Mechanisms of Cancer Program, Centro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-9398-6072
Universidad de Salamanca · ES

Funding

Asociación Española Contra el Cáncer GC16173472GARCCaixaBank HR20-00164Fundación Ramón Areces BEVP32P01S10090Junta de Castilla y León CSI252P18, CSI145P20, CLC-2017-01Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Castilla-León autonomous government CLC-2017-01Spanish Ministry of Science and Innovation BES-2013-063573Spanish Ministry of Science and Innovation RTI2018-096481-B-100
6 · The paper itself

Abstract

Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.

Indexed as

HomeostasisMuscle DevelopmentAnimalsHumansMuscle, SkeletalMuscular DiseasesRegenerationrho GTP-Binding Proteinsrho GTP-Binding ProteinsCdc42GTPase activating proteinsguanosine nucleotide exchange factorsmetabolismmuscle massmuscle regenerationmyogenesispakRac1RhoArocksatellite cellssignalingsmall G protein

Identifiers

PMID34831205
PMCPMC8616218
OpenAlexW3210761856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.