Evidence map›Paper›PMID 34831171›Full record

ArticleCells2021

Decanoic Acid Stimulates Autophagy in

Eleanor C Warren, Pavol Kramár, Katie Lloyd-Jones, Robin S B Williams

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eleanor C WarrenCentre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.ORCID 0000-0001-8802-3407
Pavol KramárCentre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.
Katie Lloyd-JonesCentre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.
Robin S B WilliamsCentre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.ORCID 0000-0002-9826-6020
Royal Holloway University of London · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Ketogenic diets, used in epilepsy treatment, are considered to work through reduced glucose and ketone generation to regulate a range of cellular process including autophagy induction. Recent studies into the medium-chain triglyceride (MCT) ketogenic diet have suggested that medium-chain fatty acids (MCFAs) provided in the diet, decanoic acid and octanoic acid, cause specific therapeutic effects independent of glucose reduction, although a role in autophagy has not been investigated. Both autophagy and MCFAs have been widely studied in

Indexed as

AutophagyAutophagosomesDecanoic AcidsDictyosteliumPhosphatidylinositol PhosphatesProto-Oncogene Proteins c-aktDecanoic Acidsphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol PhosphatesProto-Oncogene Proteins c-akt4BCCA4EOAautophagycancerdecanoic acidDictyosteliumepilepsymedium-chain triglycerides

Identifiers

PMID34831171
PMCPMC8616062
OpenAlexW3209931913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.